PMID: 15235063Jul 6, 2004Paper

Inhomogeneous localization of radioactivity in the human kidney after injection of [(111)In-DTPA]octreotide

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Marion de JongEric P Krenning

Abstract

In peptide receptor radionuclide therapy (PRRT) using somatostatin analogs labeled with beta-emitters, the radiosensitive kidney is the dose-limiting organ, because of high uptake and retention of the radionuclides after glomerular filtration. Dosimetry calculations are mostly based on the MIRD scheme, assuming homogeneous renal radioactivity distribution. The aim of this study was to reveal the radioactivity distribution in the normal human kidney after intravenous injection of [(111)In-diethylenetriaminepentaacetic acid (DTPA)]octreotide. Three patients received intravenous injection of [(111)In-DTPA]octreotide before nephrectomy because of renal cancer. Distribution of radioactivity in the human kidney was investigated using SPECT scanning before and ex vivo autoradiography of the kidney after surgery. Radioactivity was localized predominantly in the cortex of the kidney. In the cortex, radioactivity was not distributed homogeneously but formed a striped pattern, with most of the radioactivity centered in the inner cortical zone. These findings show that average dose calculations using the MIRD scheme, assuming homogeneous renal radioactivity distribution, are inadequate to estimate the radiation dose to various parts of the...Continue Reading

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