Initial and subsequent response to pneumococcal polysaccharide and protein-conjugate vaccines administered sequentially to adults who have recovered from pneumococcal pneumonia.

The Journal of Infectious Diseases
Daniel M MusherMaria C Rodriguez-Barradas

Abstract

Controversy persists over the benefits of pneumococcal polysaccharide vaccine (PPV) for adults at high risk for pneumococcal disease. We studied PPV, protein-conjugate pneumococcal vaccine (PCV), and immunologic "priming" with PCV followed by "boosting" with PPV in adults who had recovered from pneumococcal pneumonia. Subjects received PPV followed by PCV 6 months later, or vice versa. The levels of IgG to capsular polysaccharide and opsonophagocytic killing activity (OPK) were studied at baseline and at 4-8 weeks and 6 months after each vaccination. PPV and PCV stimulated similar IgG levels and OPK at 4-8 weeks after vaccination. Six months after receipt of PPV, the antibody levels declined to baseline but remained modestly elevated after receipt of PCV. PCV administered 6 months after PPV stimulated modest increases in IgG level that failed to reach the peaks observed after receipt of PPV. In contrast, PPV administered 6 months after PCV caused dramatic increases in the levels of IgG and OPK for all polysaccharides at 4-8 weeks, consistent with a booster effect. Six months after receipt of the second vaccination, however, levels of IgG and OPK fell precipitously in all patients, approaching baseline levels. In these high-risk...Continue Reading

References

Nov 21, 1991·The New England Journal of Medicine·E D ShapiroJ D Clemens
Nov 20, 1986·The New England Journal of Medicine·M S SimberkoffD S Shepard
Jan 1, 1973·Advances in Experimental Medicine and Biology·W O Weigle
Mar 1, 1981·Reviews of Infectious Diseases·R Austrian
Sep 7, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Romero-SteinerG M Carlone
Feb 16, 1981·Proceedings of the American Philosophical Society·R Austrian
May 2, 2003·The New England Journal of Medicine·Lisa A JacksonUNKNOWN Vaccine Safety Datalink
Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Catherine M WernetteMoon H Nahm
Jul 11, 2003·Clinical and Diagnostic Laboratory Immunology·Kyung Hyo KimMoon H Nahm
Oct 30, 2003·The Cochrane Database of Systematic Reviews·K DearD Tatham
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherAnna Wanahita
Mar 29, 2006·The Pediatric Infectious Disease Journal·Blanca E GonzalezUNKNOWN U.S. Pediatric Multicenter Pneumococcal Surveillance Group
Apr 7, 2006·The New England Journal of Medicine·Moe H KyawUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
Apr 7, 2006·The New England Journal of Medicine·Daniel M Musher
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherMaria C Rodriguez-Barradas
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S R J AlaneeUNKNOWN International Pneumococcal Study Group
Aug 24, 2007·The Lancet Infectious Diseases·Katherine L O'BrienDavid Goldblatt
Sep 1, 1948·The Journal of Experimental Medicine·M HEIDELBERGERM M DI LAPI

❮ Previous
Next ❯

Citations

Aug 28, 2010·The Journal of Infectious Diseases·Nancy F Crum-CianfloneUNKNOWN Infectious Disease Clinical Research Program HIV Working Group
Jun 2, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark T DransfieldUNKNOWN NIH COPD Clinical Research Network
Jun 27, 2009·American Journal of Respiratory and Critical Care Medicine·Mark T DransfieldUNKNOWN COPD Clinical Research Network
Aug 1, 2012·The Australasian Medical Journal·Iman Ridda, Daniel M Musher
Sep 29, 2012·Lung India : Official Organ of Indian Chest Society·Dheeraj GuptaUNKNOWN Pneumonia Guidelines Working Group
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rajeka LazarusAndrew J Pollard
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherMaria C Rodriguez-Barradas
Apr 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tom C DartonRobert C Read
Oct 28, 2010·Der Internist·B BaboueeM Battegay
May 11, 2011·Infection·S M DoshiD M Musher
Feb 13, 2013·Infectious Disease Clinics of North America·Daniel M Musher
Sep 16, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M Musher
Apr 7, 2009·British Journal of Haematology·Helen Chapel, Charlotte Cunningham-Rundles
Nov 26, 2015·Human Vaccines & Immunotherapeutics·Daniel M Musher, Maria B Rodriguez-Barradas
Sep 4, 2015·MMWR. Morbidity and Mortality Weekly Report·Miwako KobayashiTamara Pilishvili
Jul 27, 2012·Scandinavian Journal of Infectious Diseases·Carl SpindlerUNKNOWN Community Acquired Pneumonia Working Group of The Swedish Society of Infectious Diseases
May 2, 2015·Human Vaccines & Immunotherapeutics·S DirmesropianA T Newall
Aug 21, 2013·Human Vaccines & Immunotherapeutics·Michael E Pichichero
May 10, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Joon Young SongMoon H Nahm
Jul 19, 2011·Vaccine·John D Grabenstein, Susan B Manoff
Nov 2, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M WoodheadUNKNOWN Joint Taskforce of the European Respiratory Society and European Society for Clinical Microbiology and Infectious Diseases
Nov 2, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M WoodheadUNKNOWN Joint Taskforce of the European Respiratory Society and European Society for Clinical Microbiology and Infectious Diseases
Dec 9, 2016·Human Vaccines & Immunotherapeutics·Paolo BonanniAngela Bechini
Mar 25, 2016·Clinical and Vaccine Immunology : CVI·Ioanna Papadatou, Vana Spoulou
Feb 20, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C BonnaveJ Flamaing
Dec 28, 2012·Cellular and Molecular Life Sciences : CMLS·Eliane Namie MiyajiPaulo Lee Ho
Aug 4, 2011·Expert Review of Vaccines·David S FedsonSandrine I Samson
Oct 3, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Yiling JiangXavier Bresse
Mar 23, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mariëlle van AalstAbraham Goorhuis
Oct 2, 2014·Expert Review of Vaccines·Anita S IyerMa Julie Westerink
Jul 11, 2018·Frontiers in Immunology·Lavida R K Brooks, George I Mias
Apr 22, 2021·The Biochemical Journal·J Sebastian TemmeJeffrey C Gildersleeve

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.