Initial antibiotic treatment for acute simple appendicitis in children is safe: Short-term results from a multicenter, prospective cohort study

Surgery
Ramon R GorterAPAC Study Group

Abstract

Initial antibiotic treatment for acute appendicitis has been shown to be safe in adults; so far, not much is known about the safety and efficacy of this treatment in children. The aims of this study were to investigate the feasibility of a randomized controlled trial (RCT) evaluating initial antibiotic treatment for acute appendectomy in children with acute simple appendicitis and to evaluate the safety of this approach. In a multicenter, prospective cohort study patients aged 7-17 years with a radiologically confirmed simple appendicitis were eligible. Intravenous antibiotics (amoxicillin/clavulanic acid 250/25 mg/kg 4 times daily; maximum 6,000/600 mg/d and gentamicin 7 mg/kg once daily) were administered for 48-72 hours. Clinical reevaluation every 6 hours, daily blood samples, and ultrasound follow-up after 48 hours was performed. In case of improvement after 48 hours, oral antibiotics were given for a total of 7 days. At any time, in case of clinical deterioration or non-improvement after 72 hours, an appendectomy could be performed. Follow-up continued until 8 weeks after discharge. Adverse events were defined as major complications of antibiotic treatment, such as allergic reactions, perforated appendicitis, and recurren...Continue Reading

References

Oct 8, 1998·Journal of Clinical Epidemiology·P BlomqvistA Ekbom
Apr 12, 2001·Pediatric Radiology·K L HopkinsT I Ball
Apr 12, 2001·The British Journal of Surgery·H LintulaK Vanamo
May 26, 2005·Radiology·Fraukje WiersmaHerma C Holscher
Jul 28, 2006·Pediatric Emergency Care·Yen-Shih PengYa-Huei Tsai
Jan 11, 2007·Seminars in Pediatric Surgery·Stephen E Morrow, Kurt D Newman
Aug 21, 2007·Journal of Pediatric Surgery·Musa AbeşSelçuk Kazil
Jun 6, 2008·Journal of Pediatric Hematology/oncology·Verena A WiegeringJean-Pierre Bourquin
May 30, 2009·Journal of the American College of Surgeons·Regan F WilliamsMax R Langham
Jul 16, 2010·The American Journal of Emergency Medicine·Chaitan K NarsuleFrancois I Luks
Mar 17, 2011·Pediatric Radiology·Adam B GoldinMarguerite T Parisi
May 3, 2011·World Journal of Radiology·Noh Hyuck ParkJi Yeon Park
May 27, 2011·Pediatric Surgery International·Rizwan A KhanRajendra S Chana
Nov 25, 2011·The Journal of Surgical Research·Mirelle E E BrökerTim Schepers
Jul 7, 2012·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·J F SvenssonT Wester
Aug 29, 2012·ANZ Journal of Surgery·Manju D ChandrasegaramRose J Miller
Apr 27, 2013·AJR. American Journal of Roentgenology·Einat BlumfieldTerry L Levin
May 24, 2014·Journal of Pediatric Surgery·Jeff ArmstrongAndreana Bütter

❮ Previous
Next ❯

Citations

Jul 13, 2016·Pediatric Annals·Grace Zee Mak, Deborah S Loeff
Sep 11, 2016·Journal of Pediatric Surgery·Anna Maria CarusoLuigi Mascia
Oct 16, 2016·Pediatric Surgery International·Rebecca M RenteaCharles L Snyder
Oct 31, 2016·International Journal of Surgery·Byeong Geon JeonSang-Jeon Lee
Mar 2, 2017·Pediatric Emergency Care·Susan C Lipsett, Richard G Bachur
May 10, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Fengbo SunYe Wang
Mar 18, 2017·Current Opinion in Pediatrics·Joseph J LópezPeter C Minneci
Nov 18, 2017·Journal of Paediatrics and Child Health·Andrew ReadJonathan Karpelowsky
Oct 27, 2017·Archives of Disease in Childhood·Nigel J Hall, Simon Eaton
Jan 19, 2018·Pediatric Surgery International·Zvi SteinerShmuel Arnon
Mar 7, 2018·World Journal of Emergency Surgery : WJES·Hailan ZhangWeilin Wang
Mar 11, 2018·Pediatric Surgery International·M D BolmersUNKNOWN Snapshot Appendicitis Collaborative Study group
Dec 6, 2018·The Journal of Trauma and Acute Care Surgery·David A TalanGregory J Moran
May 30, 2019·Journal of Comparative Effectiveness Research·Le-Wee BiHua-Lei Cui
Oct 3, 2019·Pediatric Surgery International·Takafumi MikamiAtsuyuki Yamataka
Oct 31, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Paul van AmstelHugo A Heij
Sep 27, 2019·Pediatric Surgery International·Chirath RanaweeraAugusto Zani
Dec 16, 2019·Pediatric Surgery International·Sonia MaitaTomas Wester
Dec 18, 2019·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Ikeoluwa Kendra Bolakale-Rufai, David O Irabor
Mar 7, 2020·Journal of Pediatric Hematology/oncology·Sarah SahibScott T Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Beta-lactamase Inhibitors (ASM)

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Beta-lactamase Inhibitors

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.