PMID: 3464616Sep 1, 1986Paper

Initial attachment of fibroblast-like cells to periodontally-diseased root surfaces in vitro

Journal of Clinical Periodontology
O FardalE Freeman


The precise factors mediating both initial cell attachment and longer term connective tissue reattachment after tissue destruction due to periodontal disease are not known. An in vitro model was used to assess initial attachment of fibroblast-like cells to periodontally-diseased root surfaces. Root fragments were obtained from freshly extracted teeth from 6 different patients. Individual roots were prepared such that a comparison could be made of initial attachment to non-instrumented diseased root surface, curetted diseased root surface and the non-diseased, non-instrumented portion of the same root. The amount of hard tissue removed by instrumentation was quantitated and kept constant between 0.9-1.0 mm. The unsterilized fragments were incubated with human gingival fibroblasts (HGF) for 1 h at 37 degrees, after which the roots were first washed to remove non-adherent cells and then photographed. The number of attached cells per unit area was quantitated from the photographs using a grid system. No significant differences could be detected between the numbers of cells attached to the 3 types of root surfaces studied on the individual roots or between any of the roots studied. Thus, initial attachment of HGF to diseased root su...Continue Reading


Nov 1, 1975·Journal of Periodontology·J Schwartz, M Dibblee
Dec 1, 1975·Journal of Periodontal Research·P J Robinson, I M Shapiro
Nov 1, 1975·Journal of Periodontology·J J AleoP A Farber
Nov 1, 1976·Journal of Dental Research·J D Aleo, F A De Renzis
Mar 1, 1972·Journal of Dental Research·R Snyderman
Mar 1, 1970·Journal of Periodontology·L A NortonR R Moore
Apr 1, 1973·Archives of Oral Biology·M E Neiders, L Weiss
Apr 1, 1983·Journal of Periodontology·T J O'Leary, A H Kafrawy
Dec 1, 1980·Journal of Periodontology·L J AdelsonR G Caffesse

❮ Previous
Next ❯


Jun 25, 2005·Journal of Periodontology·Amer Sayed-SuleymanThomas Lallier
Sep 16, 2011·ISRN Obstetrics and Gynecology·Laurie ElitWaldo Jimenez
Dec 11, 2007·Journal of Biomedical Materials Research. Part a·Luca RaffaelliGabriella Calviello
Aug 1, 1989·Endodontics & Dental Traumatology·R WongN G Clarke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.