Initial butyrate producers during infant gut microbiota development are endospore formers.

Environmental Microbiology
Olivia AppertClarissa Schwab

Abstract

The acquisition of the infant gut microbiota is key to establishing a host-microbiota symbiosis. Microbially produced metabolites tightly interact with the immune system, and the fermentation-derived short-chain fatty acid butyrate is considered an important mediator linked to chronic diseases later in life. The intestinal butyrate-forming bacterial population is taxonomically and functionally diverse and includes endospore formers with high transmission potential. Succession, and contribution of butyrate-producing taxa during infant gut microbiota development have been little investigated. We determined the abundance of major butyrate-forming groups and fermentation metabolites in faeces, isolated, cultivated and characterized the heat-resistant cell population, which included endospores, and compared butyrate formation efficiency of representative taxa in batch cultures. The endospore community contributed about 0.001% to total cells, and was mainly composed of the pioneer butyrate-producing Clostridium sensu stricto. We observed an increase in abundance of Faecalibacterium prausnitzii, butyrate-producing Lachnospiraceae and faecal butyrate levels with age that is likely explained by higher butyrate production capacity of con...Continue Reading

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Citations

Jan 8, 2021·Gut Microbes·Muireann EganCatherine Stanton
Jan 12, 2021·FEMS Microbiology Reviews·Martin Frederik LaursenTine Rask Licht
Mar 9, 2021·The Science of the Total Environment·Joel E BrameMartin F Breed
Feb 16, 2021·Environmental Microbiology·Alejandro Ramirez GarciaClarissa Schwab
Apr 4, 2021·International Journal of Molecular Sciences·Naschla GasalyMartín Gotteland

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