Initial characterization of PMMA as a discriminative stimulus

Pharmacology, Biochemistry, and Behavior
R A GlennonY Cheng

Abstract

The phenylisopropylamine PMMA or N-methyl-1-(4-methoxyphenyl)-2-aminopropane, a structural hybrid of paramethoxyamphetamine (PMA) and methamphetamine, has been previously shown to unexpectedly lack amphetamine-like or hallucinogen-like stimulus properties in animals. For example, in tests of stimulus generalization, neither a (+)amphetamine stimulus nor a DOM stimulus generalized to PMMA. It has also been shown, however, that stimulus generalization does occur in animals trained to discriminate the designer drug MDMA ("Ecstasy" or N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane) from vehicle. In order to further characterize this unique agent, we trained a group of six Sprague-Dawley rats to discriminate 1.25 mg/kg of PMMA (ED50 = 0.44 mg/kg) from saline vehicle. The PMMA stimulus failed to generalize to the phenylisopropylamine stimulant (+)amphetamine, or to the phenylisopropylamine hallucinogen DOM. Stimulus generalization occurred to (+/-)MDMA (ED50 = 1.32 mg/kg) and S(+)MDMA (ED50 = 0.48 mg/kg). Partial generalization occurred with R(+)MDMA, PMA, 3.4-DMA, and fenfluramine. The PMMA stimulus also generalized to the alpha-ethyl homolog of PMMA (EH/PMMA, ED50 = 1.29 mg/kg). Taken together, the results of these studies su...Continue Reading

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Citations

Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·J B RangisettyR A Glennon
Nov 10, 2001·Pharmacology, Biochemistry, and Behavior·S S HongR A Glennon
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Richard A GlennonJagadeesh B Rangisetty
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Richard A Glennon, Richard Young
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Malgorzata DukatRichard A Glennon
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R A Glennon
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R YoungR A Glennon
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Jon C Cole, Harry R Sumnall
Sep 20, 2012·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Wei-Hsi ChenHsin-Ling Yin
Oct 12, 2013·Life Sciences·Anita H LewinP Anantha Reddy
Dec 14, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Yael LurieYedidia Bentur
May 8, 2003·Journal of Toxicology. Clinical Toxicology·David G E CaldicottRod J Irvine
Oct 27, 2015·Neurotoxicity Research·Krystyna GołembiowskaAnna Górska
Nov 18, 2003·Acta Anaesthesiologica Scandinavica·S Refstad
Dec 21, 2010·Pharmacology, Biochemistry, and Behavior·Tomáš PáleníčekCyril Höschl
Apr 11, 2012·Pharmacology, Biochemistry, and Behavior·Adam L HalberstadtMark A Geyer
Mar 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Roland F StaackHans H Maurer
May 13, 2020·Annals of the New York Academy of Sciences·F Ivy CarrollP Anantha Reddy
Nov 19, 2011·Annals of the New York Academy of Sciences·F Ivy CarrollP Anantha Reddy

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