Initial derivation of diagnostic clusters combining history elements and physical examination tests for symptomatic knee osteoarthritis

Musculoskeletal Care
S DécaryF Desmeules

Abstract

The aim of the present study was to assess the validity of clusters combining history elements and physical examination tests to diagnose symptomatic knee osteoarthritis (SOA) compared with other knee disorders. This was a prospective diagnostic accuracy study, in which 279 consecutive patients consulting for a knee complaint were assessed. History elements and standardized physical examination tests were obtained independently by a physiotherapist and compared with an expert physician's composite diagnosis, including clinical examination and imaging. Recursive partitioning was used to develop diagnostic clusters for SOA. Diagnostic accuracy measures were calculated, including sensitivity, specificity, and positive and negative likelihood ratios (LR+/-), with associated 95% confidence intervals (CIs). A total of 129 patients had a diagnosis of SOA (46.2%). Most cases (76%) had combined tibiofemoral and patellofemoral knee OA and 63% had radiological Kellgren-Lawrence grades of 2 or 3. Different combinations of history elements and physical examination tests were used in clusters accurately to discriminate SOA from other knee disorders. These included age of patients, body mass index, presence of valgus/varus knee misalignment, ...Continue Reading

References

May 29, 2007·Arthritis and Rheumatism·George PeatPeter Croft
Nov 21, 2007·Health Technology Assessment : HTA·A W S RutjesP M M Bossuyt
May 19, 2009·Journal of Clinical Epidemiology·Johannes B ReitsmaPatrick M Bossuyt
Sep 19, 2009·Annals of the Rheumatic Diseases·W ZhangJ W Bijlsma
Jan 5, 2010·The Journal of Manual & Manipulative Therapy·Eric J Hegedus, Ben Stern
Mar 16, 2012·Arthritis Research & Therapy·George PeatSara Muller
Aug 21, 2013·Journal of Clinical Epidemiology·Penny F WhitingUNKNOWN QUADAS-2 Steering Group
Sep 3, 2013·The European Journal of General Practice·Søren T SkouOle H Simonsen
Sep 17, 2013·Archives of Physical Medicine and Rehabilitation·Anat Lubetzky-VilnaiSarah Westcott McCoy
Mar 4, 2014·Journal of Clinical Epidemiology·Nicholas HenschkeArianne P Verhagen
Mar 4, 2014·Osteoarthritis and Cartilage·D SchiphofS M A Bierma-Zeinstra
Jan 13, 2015·The Journal of Orthopaedic and Sports Physical Therapy·Jason RodegheroJulie M Whitman
Mar 18, 2015·Arthritis Care & Research·Rohit AggarwalBrian M Feldman
Jul 19, 2015·European Journal of Internal Medicine·Yasmaine H J M KarelArianne P Verhagen
Oct 30, 2015·Clinical Chemistry·Patrick M BossuytUNKNOWN STARD Group
Aug 2, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Muyibat A AdelaniRick W Wright
Sep 12, 2016·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Richard Michael PageMatt Greig
Sep 14, 2016·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Lucas Rafael HelenoChristiane de S Guerino Macedo
Apr 9, 2017·Annals of the Rheumatic Diseases·Garifallia SakellariouAnnamaria Iagnocco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.