Initial evaluation of the use of USPIO cell labeling and noninvasive MR monitoring of human tissue-engineered vascular grafts in vivo.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Gregory N NelsonChristopher K Breuer

Abstract

This pilot study examines noninvasive MR monitoring of tissue-engineered vascular grafts (TEVGs) in vivo using cells labeled with iron oxide nanoparticles. Human aortic smooth muscle cells (hASMCs) were labeled with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. The labeled hASMCs, along with human aortic endothelial cells, were incorporated into eight TEVGs and were then surgically implanted as aortic interposition grafts in a C.B-17 SCID/bg mouse host. USPIO-labeled hASMCs persisted in the grafts throughout a 3 wk observation period and allowed noninvasive MR imaging of the human TEVGs for real-time, serial monitoring of hASMC retention. This study demonstrates the feasibility of applying noninvasive imaging techniques for evaluation of in vivo TEVG performance.

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Citations

Sep 18, 2010·Tissue Engineering. Part B, Reviews·Chiara VillaYvan Torrente
Sep 16, 2009·Tissue Engineering. Part C, Methods·Jesper HjortnaesElena Aikawa
Aug 19, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jamie K HarringtonChristopher K Breuer
Sep 24, 2009·Journal of Biomedical Science·Huey-Chung HuangFu-Hsiung Chang
Mar 24, 2011·Future Medicinal Chemistry·Sophie LaurentRobert N Muller
Sep 24, 2014·Radiology·Fabian KiesslingTwan Lammers
Jul 14, 2010·Journal of Pediatric Surgery·Tamar L MirenskyChristopher K Breuer
Apr 16, 2009·Contrast Media & Molecular Imaging
Mar 6, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Animesh RathoreChristopher Breuer
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Sep 19, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Shirjel R AlamDavid E Newby
Jun 19, 2013·Biomaterials·Alyssa A AppelEric M Brey
Oct 9, 2012·International Journal of Cardiology·Lynda V ThomasPrabha D Nair
Jul 7, 2018·Tissue Engineering. Part C, Methods·Mitchel R StacyChristopher K Breuer
Sep 12, 2013·Biomedizinische Technik. Biomedical Engineering·Julia FreseFabian Kiessling
Feb 27, 2014·Advanced Functional Materials·Marianne E MertensTwan Lammers
Jun 7, 2020·Tissue Engineering. Part B, Reviews·Sin-Guang ChenChien-Ling Huang
Jul 3, 2021·International Journal of Molecular Sciences·Jörg SchmehlStefanie Elser
Apr 11, 2016·ACS Biomaterials Science & Engineering·Stacey M FortonErik M Shapiro

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