PMID: 9165452May 1, 1997Paper

Initial experience with FK506 (tacrolimus) in pediatric renal transplant recipients

Journal of Pediatric Surgery
M McKeeP Colombani

Abstract

The efficacy and safety of the new immunosuppressant agent, FK506 (tacrolimus), was assessed in pediatric renal transplant recipients over a mean 12-month follow-up period. Twenty pediatric renal transplant recipients received oral FK506 therapy (0.3 mg/kg/d) in combination with azathioprine (1 to 2 mg/kg/d) and low-dose prednisone as primary therapy (n = 11) or were converted from cyclosporine-based therapy (n = 9) for complications including cyclosporine toxicity (n = 2), acute refractory rejection (n = 4), and chronic rejection (n = 3). Patients were then followed-up prospectively to evaluate effectiveness of therapy and complications. In the primary treatment group, 45% of patients had one or more rejection episodes. Two required OKT3 therapy (18%) for persistent rejection, with one (9%) graft loss at 3 months. All other episodes were treated effectively with FK506 dose adjustment and steroid pulses. Patient and graft survival was 100% and 91%, respectively, at 12 months mean follow-up. In the FK506 conversion group, two teenage girls with intractable acne and hirsutism were converted with complete resolution and no change in renal function. Four patients were converted for acute rejection: two who did not respond to steroi...Continue Reading

Citations

May 17, 2000·Transplantation Proceedings·M HaberalM Coşkun
Mar 27, 2001·Transplantation Proceedings·S ShishidoH Nakai
Aug 15, 2002·Transplantation Proceedings·A HasegawaUNKNOWN Japanese Tacrolimus Study Group
Sep 2, 1998·Transplantation Proceedings·R B Ettenger
Nov 27, 1999·Transplantation Proceedings·M L JordanT E Starzl
Mar 3, 1998·Journal of the American College of Surgeons·R G Azizkhan
Feb 12, 1999·Transplantation·R ShapiroT E Starzl
Feb 24, 2007·Nephrology·Steven McTaggart, UNKNOWN Caring for Australians with Renal Impairment (CARI)
Apr 1, 2005·American Journal of Clinical Dermatology·Kristine BreuerAlexander Kapp
Apr 1, 2006·Der Nervenarzt·J Finsterer
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Sandrine GuisFrédéric Lioté
Oct 13, 2006·Pediatric Transplantation·Ron Shapiro
Oct 19, 2011·Pediatric Transplantation·Belde Kasap
Jan 5, 2002·Seminars in Cutaneous Medicine and Surgery·N RobinsonK B Gordon
Apr 24, 2003·Clinical Transplantation·Markus J KemperThomas J Neuhaus
Apr 17, 2001·Pediatric Annals·A Spray, E Siegfried

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