Initial experience with the unrestricted introduction of sugammadex at a large academic medical center: a retrospective observational study examining postoperative mechanical ventilation and efficiency outcomes

Korean journal of anesthesiology
Vikas N O'Reilly-ShahFrancis A Wolf

Abstract

Sugammadex rapidly reverses deep neuromuscular blockade, but owing to cost, questions remain about its optimal utilization. After the unrestricted introduction of sugammadex at Emory University Hospital, we hypothesized that reductions would be demonstrated in the primary outcome of post-anesthesia care unit (PACU) mechanical ventilation (MV) and secondary outcomes of PACU length of stay (LOS) and emergence time (surgery end to anesthesia end time in the PACU). This retrospective observational study included patients undergoing general anesthesia over a 12-month period. Using multiple variable penalized logistic regression in a one-group before-and-after design, we compared the categorized rates of PACU MV to examine the effect of sugammadex introduction following a post-hoc chart review to ascertain the reason for postoperative MV. Additionally, multiple variable linear regression was used to assess for differences in PACU LOS and emergence time within a propensity-matched set of patients receiving neostigmine or sugammadex. In total, 7,217 surgical cases met the inclusion criteria: 3,798 before and 3,419 after sugammadex introduction. The incidence of PACU MV was 2.3% before and 1.8% after (P = 0.118) sugammadex introduction....Continue Reading

References

Sep 5, 2002·Statistics in Medicine·Georg Heinze, Michael Schemper
Sep 30, 2005·Anesthesiology·Francois GijsenberghThijs van Iersel
Feb 22, 2007·Anesthesia and Analgesia·Mohamed Naguib
May 13, 2017·Journal of Clinical Anesthesia·Michele CarronCarlo Ori
Aug 15, 2017·The Cochrane Database of Systematic Reviews·Ana-Marija HristovskaArash Afshari
Sep 1, 2017·British Journal of Anaesthesia·V N O'Reilly-ShahG C Lynde

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Citations

Aug 5, 2020·Korean journal of anesthesiology·Sung Yong Park
Jul 6, 2019·Current Pharmaceutical Design·Jesse HawkinsMaged Argalious

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