Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis

Scientific Reports
Bianca C G LisboaHelena Brentani

Abstract

Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by obsessions and/or compulsions. Different striatal subregions belonging to the cortico-striato-thalamic circuitry (CSTC) play an important role in the pathophysiology of OCD. The transcriptomes of 3 separate striatal areas (putamen (PT), caudate nucleus (CN) and accumbens nucleus (NAC)) from postmortem brain tissue were compared between 6 OCD and 8 control cases. In addition to network connectivity deregulation, different biological processes are specific to each striatum region according to the tripartite model of the striatum and contribute in various ways to OCD pathophysiology. Specifically, regulation of neurotransmitter levels and presynaptic processes involved in chemical synaptic transmission were shared between NAC and PT. The Gene Ontology terms cellular response to chemical stimulus, response to external stimulus, response to organic substance, regulation of synaptic plasticity, and modulation of synaptic transmission were shared between CN and PT. Most genes harboring common and/or rare variants previously associated with OCD that were differentially expressed or part of a least preserved coexpression module in our study also suggest stria...Continue Reading

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Citations

May 6, 2020·Molecular Psychiatry·Michel EngelnMary Kay Lobo
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susanne E Ahmari, Scott L Rauch

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Methods Mentioned

BETA
Dot blot

Software Mentioned

Homologene
eggNOG
Modular Single - set Enrichment Test tool
Ensembl
HGNC
OrthoDB
orthoMCL
Panther
Isobase
DRSC

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