Sep 1, 2005

Initial findings on teratological and developmental relationships and differences between neural tube defects and facial clefting. First experimental results

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Jens WeingaertnerKarsten K H Gundlach

Abstract

Unless genetically caused, the occurrence of neural tube defects and clefts of the lip, alveolus and palate are not associated. These malformations do, however, share some common causes, one of which is folic acid deficiency. Nevertheless, it is not known why a neural tube defect resulting from folic acid deficiency does not occur in combination with facial clefts. Based on animal experiments and a review of the literature, it is assumed that other factors--such as vitamin B6 deficiency--though clinically not diagnosed, can more often cause malformations.

  • References10
  • Citations4

References

  • References10
  • Citations4

Citations

Mentioned in this Paper

Embryo
Metabolic Process, Cellular
Neural Tube
Tooth Socket
Derivatives
Protein Methylation
Entire Embryo
Iniencephaly
Cleft Palate, Isolated
Sulfur

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