PMID: 9184308May 31, 1997Paper

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2, 11, 13, 14, and X

American Journal of Medical Genetics
O C StineJ Raymond DePaulo

Abstract

We report on an initial genome screen of 540 individuals from 97 families collected as part of the NIMH Genetics Initiative Bipolar Group. Among the individuals studied, 232 were diagnosed with bipolar (BP) I, 72 with BPII, 88 with major depressive disorder-recurrent type (UPR), and 32 with schizoaffective disorder, bipolar type (SA/BP). A total of 53 markers on chromosomes 2, 11, 13, 14, and X (average spacing: 11.5 cM) were studied at Johns Hopkins University. Tests for linkage were performed using nonparametric affected sib-pair and whole pedigree methods with three definitions of affected status. Three regions of interest were identified (13q14-32, Xp22, and Xq26-28). On chromosomes 2, 11, and 14, a disease locus with relative risk lambda(i) = 1.5 could be excluded in <10% of the genetic distance studied, while a locus conferring lambda(i) = 3 or greater could be excluded across at least 96%. The autosomal region that could not be excluded even with lambda(i) = 5 was near 13q14-32. In this region, two-point affected sib-pair analyses revealed a pair of consecutive loci with excess sharing (P < 0.05) and a multipoint affected sib-pair LOD score of 1.12. On the X chromosome, nonparametric multipoint affected sib-pair analyses...Continue Reading

Citations

May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·S D Detera-WadleighE S Gershon
Aug 18, 2006·Schizophrenia Bulletin·Rami Abou JamraMarkus M Nöthen
Nov 20, 2008·Psychiatric Genetics·Lixiang LiuJohn I Nurnberger
Jan 29, 2009·European Journal of Human Genetics : EJHG·Michel MaziadeChantal Mérette
Dec 17, 2009·Molecular Psychiatry·L M FioriG Turecki
Jun 8, 2002·Annual Review of Neuroscience·W Maxwell CowanSteven E Hyman
Jul 27, 2002·Annual Review of Genomics and Human Genetics·Pamela Sklar
May 24, 2015·Journal of Affective Disorders·Emmanuelle C S BostockBruce V M Taylor

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