Initial healing rates of venous ulcers: are they useful as predictors of healing?

American Journal of Surgery
D P HillGeorge W Cherry

Abstract

Clinical trials that follow venous ulcers to complete healing can be costly because of the prolonged healing time involved. Initial healing rates in venous ulcers are calculated by 2 methods, which are based on a metric using wound area and perimeter. It has been proposed that these rates allow the prediction of complete healing and that they may be useful as surrogate end points for clinical trials. The objective of this study was to compare the 2 proposed methods for calculating initial healing rates and determine their usefulness in predicting the healing of venous ulcers. Venous leg ulcers from patients enrolled in a randomized, double-blind, placebo-controlled study were measured weekly for up to 12 weeks. Their healing status was determined for up to 24 weeks. Initial healing rates were calculated using the 2 proposed methods. The ability of these rates to predict time to complete healing was assessed. Information from 17 patients was available. The initial healing rates, calculated by either method, were quite similar; both methods produced the same median value of 0.046 cm/week in our patients. Five of the patients had negative initial healing rates, which do not allow any prediction of a healing time. Three of 7 patien...Continue Reading

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Citations

Oct 14, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Stanislava TzanevaKornelia Böhler
Jan 31, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·M de la BrassinneL-I L Horvat
Jan 24, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Matthew CardinalKeith Harding
May 3, 2006·International Wound Journal·David L SteedMartin C Robson
Jul 5, 2016·Archives of Physical Medicine and Rehabilitation·Marylou GuihanBarbara M Bates-Jensen
Jun 16, 2018·The Cochrane Database of Systematic Reviews·Gill NormanJo C Dumville
Jul 22, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Nada Kecelj LeskovecTomaz Lunder
Sep 30, 2006·International Wound Journal·Keith MooreKeith G Harding
Jun 11, 2021·Seminars in Interventional Radiology·Sarah E Schroeppel DeBackerJeffrey L Weinstein
Nov 17, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Yung LeeMichael C Stacey

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