Initial high anti-emetic efficacy of granisetron with dexamethasone is not maintained over repeated cycles

British Journal of Cancer
R de WitJ Wils

Abstract

We have reported previously that the anti-emetic efficacy of single agent 5HT3 antagonists is not maintained when analysed with the measurement of cumulative probabilities. Presently, the most effective anti-emetic regimen is a combination of a 5HT3 antagonist plus dexamethasone. We, therefore, assessed the sustainment of efficacy of such a combination in 125 patients, scheduled to receive cisplatin > or = 70 mg m(-2) either alone or in combination with other cytotoxic drugs. Anti-emetic therapy was initiated with 10 mg of dexamethasone and 3 mg of granisetron intravenously, before cisplatin. On days 1-6, patients received 8 mg of dexamethasone and 1 mg of granisetron twice daily by oral administration. Protection was assessed during all cycles and calculated based on cumulative probability analyses using the method of Kaplan-Meier and a model for transitional probabilities. Irrespective of the type of analysis used, the anti-emetic efficacy of granisetron/dexamethasone decreased over cycles. The initial complete acute emesis protection rate of 66% decreased to 30% according to the method of Kaplan-Meier and to 39% using the model for transitional probabilities. For delayed emesis, the initial complete protection rate of 52% de...Continue Reading

Citations

Jun 24, 2004·Clinical Journal of Oncology Nursing·Linda A Flemm
Apr 27, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vito LorussoAntonio Gnoni
Feb 28, 2002·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jørn Herrstedt
Aug 3, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kenjiro AogiNoriyuki Masuda
Aug 21, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Christina H RuhlmannJørn Herrstedt
Oct 31, 2018·European Journal of Pain : EJP·Nancy PaniaguaRocio Girón
Nov 27, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mark G KrisEnzo Ballatori
Oct 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R de WitK J Horgan
Jun 19, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Julia K WarrMichelle S Mah
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Eva Ellebaek, Jørn Herrstedt
Mar 29, 2007·Internal Medicine Journal·J A A Osorio-SanchezB Koczwara
Mar 14, 2008·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Alexandre ChanLita Chew
Nov 8, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Marta Martín-RuízRaquel Abalo
Nov 30, 2016·Expert Review of Clinical Pharmacology·Bernardo RapoportTeresa Smit

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R de WitK J Horgan
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Fausto RoilaGuido Margutti
© 2022 Meta ULC. All rights reserved