Initial Hyperleukocytosis and Neutrophilia in Nasopharyngeal Carcinoma: Incidence and Prognostic Impact

PloS One
Zhen SuFang-Yun Xie

Abstract

This study aimed to evaluate initial hyperleukocytosis and neutrophilia as prognostic indicators in patients with nasopharyngeal carcinoma. A retrospective analysis of 5,854 patients identified from a cohort of 6,035 patients diagnosed with nasopharyngeal carcinoma was performed with initial hyperleukocytosis and neutrophilia analyzed as prognostic factors. Multivariate Cox proportional hazards analyses were applied. Hyperleukocytosis was observed in 508 patients (8.7%). Multivariate analysis showed that initial hyperleukocytosis was an independent predictor of death (HR 1.40, 95%CI 1.15-1.70, p = 0.001), progression (HR 1.25, 95%CI 1.06-1.47, p = 0.007) and, marginally, distant metastasis (HR 1.21, 95%CI 0.97-1.52, p = 0.088). Neutrophilia was also an independent predictor of death (HR 1.46, 95%CI 1.18-1.81, p = 0.001), progression (HR 1.31, 95%CI 1.10-1.56, p = 0.003), and distant metastasis (HR 1.29, 95%CI 1.02-1.65, p = 0.036), after adjusting for prognostic factors and excluding hyperleukocytosis. Initial hyperleukocytosis and neutrophilia were independent, poor prognostic factors and may be convenient and useful biological markers for survival of patients with nasopharyngeal carcinoma.

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Citations

Apr 29, 2018·Journal of Gastrointestinal Cancer·Joey Mercier, Ioannis A Voutsadakis
Oct 26, 2018·Journal of Gastrointestinal Cancer·AnnaLee PolicicchioIoannis A Voutsadakis
Mar 9, 2017·Aging·Tomohiro F NishijimaHyman B Muss
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Apr 20, 2021·Laryngoscope Investigative Otolaryngology·Lisha ChenChuanben Chen

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