Initial implementation of the conversion from the energy-subtracted CT number to electron density in tissue inhomogeneity corrections: an anthropomorphic phantom study of radiotherapy treatment planning

Medical Physics
Masayoshi TsukiharaMasatoshi Saito

Abstract

To achieve accurate tissue inhomogeneity corrections in radiotherapy treatment planning, the authors had previously proposed a novel conversion of the energy-subtracted computed tomography (CT) number to an electron density (ΔHU-ρ(e) conversion), which provides a single linear relationship between ΔHU and ρ(e) over a wide range of ρ(e). The purpose of this study is to present an initial implementation of the ΔHU-ρ(e) conversion method for a treatment planning system (TPS). In this paper, two example radiotherapy plans are used to evaluate the reliability of dose calculations in the ΔHU-ρ(e) conversion method. CT images were acquired using a clinical dual-source CT (DSCT) scanner operated in the dual-energy mode with two tube potential pairs and an additional tin (Sn) filter for the high-kV tube (80-140 kV/Sn and 100-140 kV/Sn). Single-energy CT using the same DSCT scanner was also performed at 120 kV to compare the ΔHU-ρ(e) conversion method with a conventional conversion from a CT number to ρ(e) (Hounsfield units, HU-ρ(e) conversion). Lookup tables for ρ(e) calibration were obtained from the CT image acquisitions for tissue substitutes in an electron density phantom (EDP). To investigate the beam-hardening effect on dosimetric...Continue Reading

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Citations

Mar 16, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wouter van ElmptFrank Verhaegen
Sep 3, 2016·Medical Physics·Jessie Y HuangStephen F Kry
May 23, 2018·Physics in Medicine and Biology·Kuan-Hao SuRaymond F Muzic
Apr 25, 2020·Medical Physics·Mikaël SimardHugo Bouchard
Mar 19, 2020·Physics in Medicine and Biology·Mikaël SimardHugo Bouchard
Dec 10, 2015·Physics in Medicine and Biology·Luis Isaac Ramos GarciaJulio F Almansa
Jun 24, 2018·Australasian Physical & Engineering Sciences in Medicine·Mohammad J Tahmasebi BirganiMohammad A Mosleh-Shirazi
Apr 16, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Kuo MenPeng Huang
Aug 15, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Kai-Wen LiLi-Sheng Geng

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