Initial lymphocyte count and the development of persistent/chronic immune thrombocytopenic purpura

Pediatric Blood & Cancer
Ibrahim AhmedMeera Chitlur

Abstract

Acute immune thrombocytopenic purpura (ITP) is a common, benign, self-limiting disease in children. Chronic ITP is diagnosed when thorombocytopenia persists beyond 12 months. Older age is associated with increased risk for development of chronic ITP. The main objective of the current study was to examine whether total leukocyte (TLC) and absolute lymphocyte counts (ALC) at diagnosis correlate with the persistence of ITP beyond 6 months. Two hundred and twenty four consecutive medical records for patients diagnosed with immune thrombocytopenia, between April 1993 and July 2007, were reviewed and 188 patients were eligible for analysis. Case records were examined to ascertain the following information: age, gender, ethnicity, date of presentation, presenting CBC with differential count, treatment given and the outcome. The male to female ratio was almost 1:1; 24% (45/188) of patients had persistent ITP beyond 6 months. We determined that age >8.5 year, TLC < 6,250/microl and ALC < 3,050/microl was associated with a significant risk for development of persistent ITP beyond 6 months. TLC and ALC at diagnosis are predictive variables for the development of persistent/chronic ITP. Further studies are recommended to confirm the curren...Continue Reading

References

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Citations

Jan 7, 2014·European Journal of Pediatrics·Veerle Labarque, Chris Van Geet
Sep 17, 2013·Pediatric Blood & Cancer·Michael D DeelSalvatore J Bertolone
Feb 15, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sinan AkbayramAhmet Faik Oner
Jan 8, 2021·International Journal of General Medicine·Ying SunWenjun Liu

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