Initial mechanisms of the development of hypertonic heart

Bulletin of Experimental Biology and Medicine
V A FrolovM L Blagonravov

Abstract

In rabbits, arterial hypertension was simulated according to Goldblatt. One, 2, 4, and 6 weeks after surgery, the hearts of control and experimental animals were extirpated for morphological examination. In semithin sections of the left and right ventricles, morphometry was performed using an Avtandilov grid. Ultrathin sections of these organs were examined under an electron microscope. It was found that the initial signs of myocardial hypertrophy appeared soon after hypertension modeling, and more early in the right ventricle. Activation of apoptosis was noted in cardiomyocytes of both ventricles, and its intensity correlated with the degree of myocardial hypertrophy. It is hypothesized that apoptosis limits the development of hypertrophy in the myocardium.

Citations

Jul 20, 2005·Bulletin of Experimental Biology and Medicine·V A FrolovM Blagonravov
Nov 12, 2005·Bulletin of Experimental Biology and Medicine·M L Blagonravov, V A Frolov
Jan 12, 2012·Bulletin of Experimental Biology and Medicine·M L BlagonravovV A Frolov
Mar 24, 2012·Bulletin of Experimental Biology and Medicine·V A FrolovT J Zotova
Dec 27, 2008·Bulletin of Experimental Biology and Medicine·M L Blagonravov

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