Initial Molecular-Level Response to Artificial Selection for Increased Aerobic Metabolism Occurs Primarily through Changes in Gene Expression

Molecular Biology and Evolution
Mateusz KonczalPaweł Koteja

Abstract

Experimental evolution combined with genome or transcriptome resequencing (Evolve and Resequence) represents a promising approach for advancing our understanding of the genetic basis of adaptation. Here, we applied this strategy to investigate the effect of selection on a complex trait in lines derived from a natural population of a small mammal. We analyzed the liver and heart transcriptomes of bank voles (Myodes [=Clethrionomys] glareolus) that had been selected for increased aerobic metabolism. The organs were sampled from 13th generation voles; at that point, the voles from four replicate selected lines had 48% higher maximum rates of oxygen consumption than those from four control lines. At the molecular level, the response to selection was primarily observed in gene expression: Over 300 genes were found to be differentially expressed between the selected and control lines and the transcriptome-wide pattern of expression distinguished selected lines from controls. No evidence for selection-driven changes of allele frequencies at coding sites was found: No single nucleotide polymorphism (SNP) changed frequency more than expected under drift alone and frequency changes aggregated over all SNPs did not separate selected and c...Continue Reading

References

Apr 11, 1975·Science·M C King, A C Wilson
Jan 1, 1989·Critical Reviews in Biochemistry and Molecular Biology·C B NewgardR J Fletterick
Nov 10, 1998·The Biochemical Journal·M BollenW Stalmans
Jan 17, 2003·BMC Genomics·Tim C RoloffUlrike A Nuber
Sep 18, 2004·Peptides·Loïc BriandJean-Claude Pernollet
Apr 5, 2005·Toxicologic Pathology·David E MalarkeyRobert R Maronpot
Apr 29, 2005·Evolution; International Journal of Organic Evolution·Edyta T SadowskaPaweł Koteja
Sep 21, 2005·The Biochemical Journal·Serkan A AlkanChristine Milcarek
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T Ohta
Feb 17, 2007·Nature Reviews. Genetics·Gregory A Wray
May 12, 2007·Evolution; International Journal of Organic Evolution·Hopi E Hoekstra, Jerry A Coyne
May 15, 2007·Nature·Tarjei S MikkelsenKerstin Lindblad-Toh
Aug 21, 2007·Journal of Inherited Metabolic Disease·N J BeauchampM J Sharrard
Nov 17, 2007·Trends in Ecology & Evolution·Rowan D H Barrett, Dolph Schluter
Jan 4, 2008·Physiological Genomics·Anja ByeUlrik Wisløff
Jul 12, 2008·Evolution; International Journal of Organic Evolution·David L Stern, Virginie Orgogozo
Sep 3, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Rieko AjimaJun Yokota
Sep 11, 2008·Physiological and Biochemical Zoology : PBZ·Edyta T SadowskaPaweł Koteja
Nov 4, 2008·Nature·Eric T WangChristopher B Burge
Jan 13, 2009·Nature Genetics·Henrique TeotónioAnthony D Long
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Jan 21, 2010·BMC Genomics·Romana StopkováPavel Stopka
Mar 17, 2010·Progress in Biophysics and Molecular Biology·Tomohiro Kurosaki, Yoshihiro Baba
Sep 17, 2010·Nature·Molly K BurkeAnthony D Long
Sep 30, 2010·BMC Bioinformatics·Murray P CoxPatrick J Biggs
Oct 12, 2010·Journal of Applied Physiology·Pernille KellerJames A Timmons
Oct 19, 2010·Trends in Ecology & Evolution·Jessica StapleyJon Slate
Nov 17, 2010·PLoS Genetics·Anna M JohanssonOrjan Carlborg
Apr 19, 2011·Medicine and Science in Sports and Exercise·James M HagbergClaude Bouchard
May 17, 2011·Trends in Ecology & Evolution·Roberto F NespoloJuan C Opazo
May 17, 2011·Nature Biotechnology·Manfred G GrabherrAviv Regev
Oct 8, 2011·Trends in Ecology & Evolution·Roger ButlinMenno Schilthuizen
Oct 8, 2011·Science·A Fournier-LevelA M Wilczek
Oct 19, 2011·Nature Reviews. Genetics·Rowan D H Barrett, Hopi E Hoekstra
Jan 10, 2012·Evolution; International Journal of Organic Evolution·Matthew V Rockman
Jan 28, 2012·Science·Olivier TenaillonBrandon S Gaut
Feb 15, 2012·Medicine and Science in Sports and Exercise·Stephen M RothClaude Bouchard

❮ Previous
Next ❯

Citations

Mar 31, 2015·Molecular Biology and Evolution·Joseph Caspermeyer
Jul 13, 2016·Molecular Biology and Evolution·Mateusz KonczalWiesław Babik
Oct 6, 2016·Behavior Genetics·Megan E GarlapowTrudy F C Mackay
Apr 17, 2015·Proceedings. Biological Sciences·Edyta T SadowskaPaweł Koteja
Jun 5, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jay F StorzTheodore Garland
Jun 14, 2019·The Plant Journal : for Cell and Molecular Biology·Muriel Gros-BalthazardBouchaib Khadari
Jun 21, 2020·The Journal of Experimental Biology·Małgorzata M LipowskaPaweł Koteja
Dec 7, 2018·Ecology and Evolution·Audrey RohfritschNathalie Charbonnel
Nov 1, 2015·The Journal of Experimental Biology·Łukasz OłdakowskiJan R E Taylor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.