Initial Presentation and Progression of Secondary Osteonecrosis of the Knee.

The Journal of Arthroplasty
Krit BoontanapibulStuart B Goodman

Abstract

Early detection and intervention are critical to maintaining the native articular cartilage before collapse in secondary osteonecrosis of the knee (SOK). We conducted a retrospective study documenting the initial stage of presentation and the progression of SOK. Our database was reviewed for patients younger than 65 years of age diagnosed with atraumatic SOK between 2002 and 2018. Demographic data, plain radiographs as well as MRI at initial evaluation, and initial treatment were classified and analyzed. One hundred four patients with 164 knees were identified. Mean age was 39 ± 16 years. Females (64%) with bilateral disease (58%) predominated. Seventy-five percent of patients had a history of corticosteroid use, of which 41% were diagnosed with hematologic malignancy and lupus. Fifteen percent of patients had a history of ethanol abuse. At initial presentation, 55% of patients were diagnosed with Ficat-Arlet stage I/II, while 45% were diagnosed with Ficat-Arlet stage III/IV. We found a significant difference in the mean age of patients at early stage of SOK with corticosteroid use (31 ± 12 years of age) when compared to ethanol use (43 ± 13 years of age, P = .02). Treatments included observation (57%), joint preservation surge...Continue Reading

References

Nov 21, 1991·The New England Journal of Medicine·P F MilnerJ Smith
Aug 1, 1989·The Journal of Bone and Joint Surgery. British Volume·M A JacobsD S Hungerford
Jan 1, 1985·The Journal of Bone and Joint Surgery. British Volume·R P Ficat
May 1, 1997·Clinical Orthopaedics and Related Research·M A MontD S Hungerford
Sep 4, 1999·The Journal of Arthroplasty·R M SeldesP A Lotke
Sep 27, 2000·The Journal of Bone and Joint Surgery. American Volume·M A MontD S Hungerford
Feb 24, 2001·Clinical Orthopaedics and Related Research·K M BaumgartenD S Hungerford
May 12, 2001·Clinical Orthopaedics and Related Research·M E SteinbergK E Hartman
Apr 10, 2002·The Journal of Bone and Joint Surgery. American Volume·Michael A MontDavid S Hungerford
Aug 2, 2002·Clinical Orthopaedics and Related Research·Naoshi FukuiKozo Nakamura
Mar 29, 2005·Pathology, Research and Practice·Goro MotomuraYukihide Iwamoto
May 25, 2006·The Journal of Bone and Joint Surgery. British Volume·G MarulandaM A Mont
Feb 19, 2008·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·M BeerK Darge
Feb 10, 2010·Clinical Orthopaedics and Related Research·Simon GörtzWilliam D Bugbee
Jun 29, 2010·Clinical Orthopaedics and Related Research·E J KarimovaS C Kaste
Aug 3, 2011·The Journal of the American Academy of Orthopaedic Surgeons·Michael A MontJohn A Carrino
Sep 29, 2011·Arthritis and Rheumatism·Ryosuke YamaguchiYukihide Iwamoto
Sep 26, 2012·Clinical Orthopaedics and Related Research·Paivi Maria MiettunenVijay Moorjani
Jun 27, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Charalampos G Zalavras, Jay R Lieberman
Jul 19, 2014·Modern Rheumatology·Kazuma IkeuchiNaoki Ishiguro
Jun 13, 2015·The Journal of Arthroplasty·Stuart B Goodman, Katherine L Hwang
Sep 22, 2015·Journal of the Chinese Medical Association : JCMA·Shang-Wen TsaiWei-Ming Chen
Nov 29, 2016·British Journal of Haematology·Annemieke S LittooijRutger A J Nievelstein
Jun 3, 2017·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Zhenxing WenJian Zhang
Jan 17, 2019·BMC Musculoskeletal Disorders·Young-Sil AnHyoun-Ah Kim
Apr 3, 2019·The Permanente Journal·Michelle J LespasioMichael A Mont
Apr 18, 2019·EFORT Open Reviews·Daniel PetekDomizio Suva

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Citations

Oct 5, 2020·The Journal of Arthroplasty·Krit BoontanapibulStuart B Goodman
Feb 24, 2021·The Journal of Arthroplasty·Krit BoontanapibulStuart B Goodman

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