Initial presentation of Pulmonary Langerhans cell histiocytosis as recurrent spontaneous pneumothoraces

Respiratory Medicine Case Reports
Ruaidhri J KeaneSeamas C Donnelly

Abstract

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease. The natural history is often unpredictable making it difficult to diagnose. We report a 63-year-old male with dyspnoea, chronic cough and recurrent respiratory tract infections, who developed progressive multifocal cystic lesions on pulmonary nodule surveillance over 4 years. He was a heavy smoker with a history of multiple spontaneous pneumothoraces in his teens. Extensive investigations culminated in a thoracoscopic wedge resection, which identified histiocytic nodules staining positive for CD1a and thus confirming the diagnosis of PLCH. It is now apparent that PLCH was the likely cause of his pneumothoraces.

References

Jan 1, 1993·Respiration; International Review of Thoracic Diseases·N SchönfeldR Loddenkemper
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·R S CrausmanT E King
Dec 24, 1997·Chest·R S Crausman, T E King
Apr 19, 2000·Thorax·A TaziA J Hance
Jul 6, 2000·The New England Journal of Medicine·R VassalloA H Limper
Apr 20, 2001·The European Respiratory Journal·J H RyuR Vassallo
Aug 4, 2001·Acta Clinica Belgica·M ThomeerUNKNOWN VRGT Working Group on Interstitial Lung Diseases
Feb 15, 2002·The New England Journal of Medicine·Robert VassalloAndrew H Limper
Oct 15, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M AricòC Danesino
Mar 15, 2006·Transplantation·Gaëlle DauriatMichel Fournier
Jun 15, 2006·The European Respiratory Journal·A Tazi
Jul 10, 2012·Respiratory Medicine·Sergio HarariJoel Moss
Oct 29, 2013·Journal of Bronchology & Interventional Pulmonology·Misbah BaqirJay H Ryu
Nov 18, 2014·British Journal of Haematology·Stephen J SimkoCarl E Allen
Apr 19, 2015·Orphanet Journal of Rare Diseases·Abdellatif TaziSylvie Chevret
Apr 23, 2015·European Journal of Internal Medicine·Davide EliaSergio Harari
Mar 2, 2016·Archives of Pathology & Laboratory Medicine·Anja C Roden, Eunhee S Yi
Apr 15, 2016·The European Respiratory Journal·Samia MourahAbdellatif Tazi
Apr 27, 2017·British Journal of Haematology·Sébastien HéritierJean Donadieu
Sep 8, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Gwenaël Lorillon, Abdellatif Tazi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
bronchoalveolar lavage
X-ray
Bronchoalveolar
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Himanshu BhardwajDavid Levin
Seminars in Respiratory and Critical Care Medicine
Brian ShawNishant Gupta
© 2021 Meta ULC. All rights reserved