Initial presentations and associated clinical findings in patients with classical congenital adrenal hyperplasia.

Journal of Pediatric Endocrinology & Metabolism : JPEM
Asmaa Adel MilyaniMashael Al-Zanbagi

Abstract

The objective of this study was to investigate the initial presenting features of children with classical congenital adrenal hyperplasia (CAH). This is a descriptive retrospective study over a period of 5 years. Data analysis was performed using Statistical Package for Social Science. Ambiguous genitalia (AG) was the commonest initial presentation marking 50.7% of the patients. On the other hand, 33.3% presented with a salt-losing crisis, 4.1% of whom presented with shock, while 14.5% had a combined presentation of both AG and a salt-losing crisis. CAH should be highly suspected in all females born with AG. Contrarily, affected male newborns more frequently present with a salt-losing crisis, and considering the recent institution of newborn screening in Saudi Arabia, earlier detection in these children is anticipated.

References

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Aug 22, 2003·The New England Journal of Medicine·Phyllis W Speiser, Perrin C White
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Apr 15, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Laura Gruñieiro-PapendieckLaura Prieto
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Nov 21, 2015·Ultrasound Quarterly·Michael Yannes, Mitchell Tublin

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Citations

Oct 24, 2019·Indian Journal of Endocrinology and Metabolism·Adnan Al ShaikhAshraf T Soliman
Jul 1, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sumudu N SeneviratneShamya de Silva
Mar 12, 2019·Pediatric Emergency Care·Catarina Ferraz Liz, Alberto Rocha

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Software Mentioned

Statistical Package for Social Sciences ( SPSS ) SPSS
Phoenix

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