Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection.

Infection and Immunity
K KellyR G Rank

Abstract

A Th1-type response develops following vaginal infection with the mouse pneumonitis biovar of Chlamydia trachomatis (MoPn). Since the type of response, i.e., Th1 versus Th2, can be influenced by factors present during T-cell activation, we examined the effects of different routes of MoPn administration on the cytokine profile and resistance against infection following a MoPn vaginal challenge. A dominant Th1-type cytokine profile developed in mice given live MoPn via the intranasal, oral, and vaginal routes with ratios of gamma interferon-secreting cells to interleukin 4-secreting cells greater than 10. In contrast, mice injected subcutaneously produced a Th2-type profile with a gamma interferon/interleukin 4 ratio of only 0.7. These mice also had significantly higher anti-MoPn immunoglobulin G1 serum titers, confirming a Th2-type cytokine profile. Exposure of mice to live MoPn, by any route prior to vaginal challenge, resulted in a shortened course of infection. However, the subcutaneous group resolved the vaginal infection more slowly, with 60% (6 of 10 mice) of the mice still isolation positive 12 days after challenge compared with only 20% of mice given live MoPn by other routes. Administration of UV-inactivated MoPn did no...Continue Reading

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Citations

Oct 13, 2006·Current Opinion in Infectious Diseases·X Yang, R C Brunham
Sep 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren C FrazerToni Darville
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toni DarvilleDavid M Ojcius
Oct 27, 2004·Infection and Immunity·Heather K MaxionKathleen A Kelly
May 1, 2009·PloS One·Cheryl I ChampionKathleen A Kelly
Mar 3, 2007·FEMS Immunology and Medical Microbiology·Vikas VatsAruna Mittal
Oct 27, 2010·Infection and Immunity·Marsha RussellCatherine M O'Connell
Feb 24, 2017·Clinical and Vaccine Immunology : CVI·Luis M de la MazaRobert C Brunham
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Apr 25, 2003·International Reviews of Immunology·Kathleen A Kelly
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Jun 22, 1999·Infection and Immunity·L L Perry, S Hughes

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