Initial serum lactate level is associated with inpatient mortality in patients with community-acquired pneumonia

The American Journal of Emergency Medicine
Min Hyuk GwakBoyoung Park

Abstract

The aim of the present study was to investigate the prognostic value of the initial serum lactate level in patients with community-acquired pneumonia (CAP). We collected data on hospitalized adult patients with CAP via the study hospital emergency department between October 2012 and September 2013. Demographics, comorbidities, and physiologic and laboratory variables including initial C-reactive protein (CRP) and serum lactate level were extracted from the electronic medical record. The primary outcome was inpatient mortality. Comparisons between survivors and nonsurvivors were performed, and multivariable logistic regression analyses were constructed as dependent variables of both continuous and categorical varieties. A total of 397 patients were enrolled, and the mortality cases were 46 (11.6%). The mean lactate level was 1.7 ± 1.4 mmol/L and was significantly higher in the nonsurvivor group than in the survivor group (2.4 ± 2.2 mmol/L vs 1.6 ± 1.2 mmol/L). In the multivariable logistic regression model for inpatient mortality constructed using lactate, CRP, and laboratory variables of pneumonia severity index (PSI), lactate and CRP remained as significant factors, but laboratory variables of PSI were not. In other multivaria...Continue Reading

References

Mar 1, 1996·Annals of Emergency Medicine·E H GilbertJ Steiner
Jan 23, 1997·The New England Journal of Medicine·M J FineW N Kapoor
Aug 3, 2004·Critical Care Medicine·H Bryant NguyenMichael C Tomlanovich
Aug 5, 2004·Infection·T WelteR Marre
Apr 28, 2005·Annals of Emergency Medicine·Nathan I ShapiroJ Woodrow Weiss
Jun 30, 2006·Critical Care : the Official Journal of the Critical Care Forum·Mirjam Christ-CrainBeat Müller
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel A MandellUNKNOWN American Thoracic Society
Sep 11, 2007·The Journal of Infection·Cristina PratVicente Ausina
Mar 11, 2008·The American Journal of Medicine·James D ChalmersAdam T Hill
Mar 28, 2009·Critical Care Medicine·Mark E MikkelsenJason D Christie
Jun 16, 2009·Critical Care : the Official Journal of the Critical Care Forum·Houman KhosravaniKevin B Laupland
Oct 14, 2009·Thorax·W S LimUNKNOWN Pneumonia Guidelines Committee of the BTS Standards of Care Committee
Dec 31, 2011·The American Journal of the Medical Sciences·Masafumi HorieYoshio Sakamoto
Jun 28, 2012·Expert Review of Anti-infective Therapy·Greg S Martin
Jan 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kim O GradelAnnmarie T Lassen
Jan 5, 2013·The Journal of Infection·Diego ViasusJordi Carratalà
Nov 15, 2013·BioMed Research International·Chun Shing KwokPhyo Kyaw Myint
Jul 26, 2014·The American Journal of Emergency Medicine·Yun-Xia Chen, Chun-Sheng Li

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Citations

Apr 27, 2017·BMC Emergency Medicine·Tibor GondosGábor Halász
Feb 23, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naveed SarmastSumeet K Asrani
Dec 23, 2017·Deutsches Ärzteblatt International·Martin Kolditz, Santiago Ewig
Jan 1, 2021·The Indian Journal of Medical Research·Aynur Ecevit KayaEngin Deniz Arslan
May 22, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aurélie WalterUNKNOWN Salvage TIPS Group

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