Initial studies on an in vivo action spectrum for melanoma induction

Progress in Biophysics and Molecular Biology
Edward C De Fabo

Abstract

Vitamin D production is initiated by exposure of 7-dehydrocholesterol in the skin to the UVB (280-320 nm) component of sunlight, resulting in the formation of photoproducts, which are subsequently metabolically activated to biologically active moieties in a series of dark reactions as described elsewhere in this symposium. Irradiation of the skin with UVB has, however, other effects not all of which are beneficial. Most notable is the initiation of skin cancer. Non-melanoma skin cancer is clearly initiated by UVB but for the most lethal of the skin cancers, cutaneous malignant melanoma, although associated with sunlight exposure, the wavelengths responsible have not been clearly identified. Using a mouse model for UV-induced melanoma, we have recently shown that UVB, not UVA (320-400 nm), is also responsible for melanoma initiation. A balance therefore needs to be struck between the healthy effects of exposure to UVB in sunlight--vitamin D formation--and the deleterious effects of which the most potentially serious is melanoma initiation. A powerful tool in determining this balance would be an understanding of the action spectra or wavelength dependence for each of these effects. Here we describe methodologies, approaches and p...Continue Reading

References

Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowA D Woodhead
Dec 22, 1999·Photodermatology, Photoimmunology & Photomedicine·T M Rünger
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·J L Bulliard
Sep 15, 2000·CA: a Cancer Journal for Clinicians·D S Rigel, J A Carucci
Jun 1, 1997·The Australasian Journal of Dermatology·B K ArmstrongD R English
Oct 24, 2000·Clinical and Experimental Dermatology·R Marks
Apr 20, 2001·Journal of the American Academy of Dermatology·S Q WangR S Bart
May 3, 2001·Journal of the National Cancer Institute·A JemalM A Tucker
Sep 21, 2001·Nature·F P NoonanG Merlino
Sep 18, 2004·Cancer Research·Edward C De FaboGlenn Merlino

❮ Previous
Next ❯

Citations

Dec 8, 2007·Arhiv za higijenu rada i toksikologiju·Gordana PehnecGlenda Sorgo
Mar 30, 2010·American Journal of Ophthalmology·Martin A Mainster, Patricia L Turner
Nov 4, 2009·Survey of Ophthalmology·Martin A Mainster, Patricia L Turner
Sep 13, 2008·The Journal of Investigative Dermatology·M Raza ZaidiGlenn Merlino
Sep 25, 2009·The British Journal of Dermatology·P Autier
Jan 26, 2007·Pigment Cell Research·Yoshinori MiyamuraVincent J Hearing
Jan 4, 2012·Photodermatology, Photoimmunology & Photomedicine·Catharina M LercheHans Christian Wulf
Jun 29, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·A JuzenieneJ Moan
Oct 12, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Johan MoanAsta Juzeniene
Jun 28, 2016·The Journal of Investigative Dermatology·Jordan M ThompsonMartin A Weinstock
May 27, 2010·British Journal of Cancer·P WorkmanUNKNOWN Committee of the National Cancer Research Institute
Jun 8, 2007·The British Journal of Dermatology·B L Diffey, P M Farr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.