Initial treatment patterns in younger adult patients with differentiated thyroid cancer in California

Thyroid : Official Journal of the American Thyroid Association
Thomas J SemradRosemary Cress

Abstract

Differentiated thyroid cancer (DTC) is among the most common malignancies in the adolescent and young adult (age 15-39 years) population, and its incidence is rising. Younger age (<45 years) is an important prognostic indicator and is incorporated into the TNM classification system. This study hypothesized that this would result in distinct treatment patterns for younger and older patients. Using the California Cancer Registry, 24,362 patients with DTC from 2004 to 2011 were identified, and they were divided into younger (<45 years) and older (≥45 years) cohorts. Demographic and clinical variables were tabulated and then compared using chi-square tests. Treatment variables included total or near total thyroidectomy, other types of thyroid surgery, and the administration of radioiodine as part of the initial treatment. Multivariable logistic regression was used to identify independent predictors of treatment administered. Younger patients were more likely to be Hispanic (32.5% vs. 21.2%) and female (82.7% vs. 74.7%), and to have papillary carcinoma (92.9% vs. 90.9%) and lymph node involvement (32.8% vs. 19.7%; p<0.0001). On multivariable analysis, younger patients (OR 1.20 [CI 1.11-1.30]), higher T-stage tumors, higher socioecon...Continue Reading

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Citations

Oct 13, 2017·Head & Neck·Anthony A FirekSalma Khan
Jun 23, 2018·Thyroid : Official Journal of the American Thyroid Association·Thomas J SemradD Gregory Farwell
Dec 22, 2017·The Journal of Clinical Endocrinology and Metabolism·Ki Wan ParkMasha J Livhits
Nov 24, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brenna E BlackburnMia Hashibe

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