Initially intact neural responses to pain in autism are diminished during sustained pain

Autism : the International Journal of Research and Practice
Michelle D FaillaCarissa J Cascio

Abstract

Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reductio...Continue Reading

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Citations

Sep 1, 2018·The European Journal of Neuroscience·Amandine LassalleNouchine Hadjikhani
Feb 11, 2020·Molecular Autism·R L MoseleyS Baron-Cohen
Feb 17, 2019·Journal of Autism and Developmental Disorders·Sarah VaughanDavid J Moore
Sep 10, 2020·Brain Sciences·Luigi Vetri
Jun 21, 2017·Molecular Autism·Michelle D FaillaCarissa J Cascio
Jul 15, 2020·Autism : the International Journal of Research and Practice·Michelle D FaillaCarissa J Cascio
Jul 6, 2019·Frontiers in Psychiatry·Sanna StrothLaura Müller-Pinzler
Mar 7, 2020·Autism Research : Official Journal of the International Society for Autism Research·Michelle D FaillaCarissa J Cascio
May 22, 2020·Neuroscience and Biobehavioral Reviews·Lidia BravoEsther Berrocoso
Feb 17, 2021·Médecine sciences : M/S·Lucien Ruelle-Le GlaunecJean-Louis Bossu
Nov 26, 2020·Pain Reports·Michelle D FaillaCarissa J Cascio
May 15, 2021·Canadian Journal of Pain = Revue Canadienne De La Douleur·Chad O BrownKarun K Singh
Jun 5, 2021·Archives of Gynecology and Obstetrics·Priscilla SamuelMark A Stokes

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