Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

Science
Dengli HongTariq Enver

Abstract

Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. By studying a monochorionic twin pair, one preleukemic and one with frank leukemia, we establish the lineal relationship between these "cancer-propagating" cells and the preleukemic cell in which the TEL-AML1 fusion first arises or has functional impact. Analysis of TEL-AML1-transduced cord blood cells suggests that TEL-AML1 functions as a first-hit mutation by endowing this preleukemic cell with altered self-renewal and survival properties.

References

May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T R GolubD G Gilliland
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi MoriMel Greaves
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Jun 7, 2003·Blood·Mel F GreavesAnthony M Ford
Sep 3, 2003·Nature Reviews. Cancer·Mel F Greaves, Joe Wiemels
Jul 10, 2004·Blood·Charlotte V CoxAllison Blair
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jan ZunaMel Greaves
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
May 24, 2005·Nature Medicine·Anders CastorSten Eirik W Jacobsen
Aug 9, 2005·Trends in Cell Biology·Jean C Y Wang, John E Dick
Mar 9, 2007·Nature·Charles G MullighanJames R Downing
Jul 21, 2007·Science·Priscilla N KellyAndreas Strasser

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Citations

Feb 16, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shabnam ShalapourThomas Kammertoens
Nov 26, 2010·Annals of Hematology·Ugo Testa
Mar 31, 2012·Frontiers of Medicine·Bingxue ShangQuansheng Zhou
Mar 28, 2013·Medical Oncology·Fetnat M TolbaDeena A Elshabrawy
Aug 9, 2011·International Journal of Hematology·Yutaka Shima, Issay Kitabayashi
May 18, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Bingxue ShangQuansheng Zhou
Dec 24, 2008·Expert Reviews in Molecular Medicine·Yigal Dror
Mar 29, 2013·Nature Communications·Euan S PolsonNorman J Maitland
Apr 1, 2011·Nature Methods·Kristin Hope, Mickie Bhatia
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Peter J CampbellMichael R Stratton
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Junji MorokumaMichael Levin
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yussanne MaRichard S Houlston
Oct 28, 2009·Carcinogenesis·C MaenhautW C G van Staveren
Jun 7, 2013·Journal of the Royal Society, Interface·Benjamin WernerArne Traulsen
Jun 3, 2010·Genes & Development·Mathieu TremblayTrang Hoang
Aug 31, 2012·Science Translational Medicine·Max JanRavindra Majeti
Sep 12, 2008·Annual Review of Pathology·Michael A Teitell, Pier Paolo Pandolfi
Jun 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark A LaBarge
Mar 17, 2009·The Journal of Clinical Investigation·Anthony M FordMel Greaves
Dec 17, 2008·Hematology·Adele K Fielding, Adele Fielding
Dec 14, 2011·Hematology·Kathrin M Bernt, Scott A Armstrong
Jan 17, 2009·Blood·Charlotte V CoxAllison Blair
Dec 10, 2008·Blood·John E Dick
Apr 13, 2011·Blood·Frederik W van DelftMel Greaves

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