Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells.

Molecular and Cellular Biology
D J Martin, B G van Ness

Abstract

The splicing patterns and sequences of two processed kappa immunoglobulin germ line mRNAs are presented. A 1.1-kilobase (kb) mRNA appeared to be derived from splicing of the previously characterized 8.4-kb germ line transcript, while a 0.8-kb mRNA was the splice product of a second 4.7-kb germ line transcript that initiated 50 base pairs upstream of J kappa 1. The interaction of the two kappa germ line promoters with nuclear binding factors is also examined. The potential role of these germ line transcripts in establishing the rearrangement potential of the locus is discussed.

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J StavnezerE Severinson
Sep 12, 1989·Nucleic Acids Research·L LeclercqM Reth
Oct 1, 1989·Molecular and Cellular Biology·D J Martin, B G Van Ness
Jan 1, 1986·Annual Review of Biochemistry·R A PadgettP A Sharp
Feb 1, 1986·Immunological Reviews·F W AltG D Yancopoulos
Jan 1, 1986·Annual Review of Immunology·G D Yancopoulos, F W Alt
Jun 25, 1986·Nucleic Acids Research·R Hromas, B Van Ness
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D Weaver, D Baltimore
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N F LandolfiP W Tucker
Nov 6, 1987·Science·H W SchroederR M Perlmutter
Nov 20, 1987·Science·F W AltG D Yancopoulos
Jan 1, 1985·Annual Review of Immunology·K L Calame
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K J NelsonR P Perry
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Apr 14, 1983·Nature·S Tonegawa
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D L Wood, C Coleclough
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R P PerryM Weigert
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B G Van NessM Weigert

❮ Previous
Next ❯

Citations

Sep 11, 2010·Seminars in Immunology·Oleg Osipovich, Eugene M Oltz
Sep 14, 2010·Seminars in Immunology·Yehudit Bergman, Howard Cedar
Mar 2, 2005·Seminars in Immunology·Anne E Corcoran
Aug 7, 2007·PLoS Biology·Stuart M ChambersMargaret A Goodell
Jun 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yanhong JiYehudit Bergman
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benjamin TaylorMatthias Merkenschlager
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rupesh H AminMark S Schlissel
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·S R CherryD Baltimore
Jul 10, 2004·Immunological Reviews·Mark S Schlissel
Jul 10, 2004·Immunological Reviews·Maya Goldmit, Yehudit Bergman
Dec 28, 2004·Nature Immunology·Maya GoldmitYehudit Bergman
Oct 2, 2004·Nature Reviews. Immunology·Yehudit Bergman, Howard Cedar
Jun 11, 2011·Nature Reviews. Immunology·Howard Cedar, Yehudit Bergman
Mar 12, 2003·The Journal of Experimental Medicine·Nandita SinghAndrew Chess
Dec 1, 1992·European Journal of Immunology·A ThompsonR K Schuurman
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SatoA Kudo
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sean P FitzsimmonsMarjorie A Shapiro
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yougui Xiang, William T Garrard
Sep 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng Peng, Laurel A Eckhardt
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S LiW T Garrard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.