Initiation and propagation of α-synuclein aggregation in the nervous system.

Molecular Neurodegeneration
Baraa A Hijaz, Laura Volpicelli-Daley

Abstract

The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of α-synuclein, called Lewy pathology. Levodopa to enhance dopaminergic transmission remains one of the most effective treatment for alleviating the motor symptoms of Parkinson's disease (Olanow, Mov Disord 34:812-815, 2019). In addition, deep brain stimulation (Bronstein et al., Arch Neurol 68:165, 2011) to modulate basal ganglia circuit activity successfully alleviates some motor symptoms. MRI guided focused ultrasound in the subthalamic nucleus is a promising therapeutic strategy as well (Martinez-Fernandez et al., Lancet Neurol 17:54-63, 2018). However, to date, there exists no treatment that stops the progression of this disease. The findings that α-synuclein can be released from neurons and inherited through interconnected neural networks opened the door for discovering novel treatment strategies to prevent the formation and spread of Lewy pathology with the goal of halting PD in its tracks. This hypothesis is based on discoveries that pathologic aggregates of α-synuclein induce the endogenous α-synuclein protein to adopt a similar pathologic confor...Continue Reading

References

Aug 28, 1997·Nature·M G SpillantiniM Goedert
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniM Goedert
Dec 2, 2000·Nature Neuroscience·R BetarbetJ T Greenamyre
Feb 24, 2001·Acta Neuropathologica·E Gómez-TortosaB T Hyman
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Feb 15, 2003·The Journal of Biological Chemistry·Sreeganga ChandraThomas C Südhof
Nov 1, 2003·Science·A B SingletonK Gwinn-Hardy
Feb 3, 2004·Annals of Neurology·Matt FarrerJ William Langston
Feb 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Francesco FornaiThomas C Südhof
Nov 5, 2005·Cell·Sreeganga ChandraThomas C Südhof
Apr 9, 2008·Nature Medicine·Jeffrey H KordowerC Warren Olanow
Nov 14, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Jeffrey H KordowerThomas B Freeman
Apr 29, 2009·Acta Neuropathologica·Thomas G BeachUNKNOWN Arizona Parkinson's Disease Consortium
Nov 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kelvin C LukVirginia M-Y Lee
Mar 4, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Jia-Yi LiPatrik Brundin
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Evangelia EmmanouilidouKostas Vekrellis
Jun 17, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Oleg S GorbatyukNicholas Muzyczka
Aug 28, 2010·Science·Jacqueline BurréThomas C Südhof
Oct 13, 2010·Archives of Neurology·Jeff M BronsteinMahlon R DeLong
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takahisa KanekiyoGuojun Bu
Aug 28, 2012·Molecular Neurodegeneration·Karin M DanzerPamela J McLean
Oct 16, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Kelly Del Tredici, Heiko Braak
Mar 5, 2013·Nature Neuroscience·Samantha J OrensteinAna Maria Cuervo
Mar 8, 2013·Brain : a Journal of Neurology·Masami Masuda-SuzukakeMasato Hasegawa
Jul 26, 2013·Brain : a Journal of Neurology·Jeffrey H KordowerRaymond T Bartus
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Brandon B HolmesMarc I Diamond
Oct 11, 2013·Nature Communications·Luc BoussetRonald Melki
Oct 23, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Helena C Christianson, Mattias Belting
May 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alexander K BuellChristopher M Dobson
May 30, 2014·Nature Communications·Giuliana FuscoGianluigi Veglia

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Citations

Oct 2, 2020·International Journal of Molecular Sciences·Fang LuoXin Wang
Sep 24, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Piotr ChmielarzAndrii Domanskyi
Jul 28, 2020·International Journal of Molecular Sciences·Elena VacchiGiorgia Melli
Jul 1, 2020·Frontiers in Cellular Neuroscience·Yuan GuanClaire Xi Zhang
Oct 9, 2020·International Journal of Molecular Sciences·Antonella SferraEnrico Bertini
Oct 20, 2020·Frontiers in Synaptic Neuroscience·Antonio Heras-Garvin, Nadia Stefanova
Dec 4, 2020·Cells·Ga Ram Jeong, Byoung Dae Lee
Nov 19, 2020·Cells·Charysse VandendriesscheRoosmarijn E Vandenbroucke
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Tsu-Kung LinTzu-Jou Wang
Feb 1, 2021·Neurochemistry International·Michele SalemiRaffaele Ferri
Dec 10, 2020·International Journal of Molecular Sciences·Grażyna GromadzkaAgata Adamczyk
Feb 23, 2021·Journal of Extracellular Vesicles·Ursula S SandauJulie A Saugstad
Mar 23, 2021·The Journal of Cell Biology·Nikhil PanickerTed M Dawson
Apr 6, 2021·Neural Regeneration Research·Piotr Chmielarz, Andrii Domanskyi
May 23, 2021·Communications Biology·Jason C SangDavid Klenerman
Jun 8, 2021·Neurochemistry International·Tingting Zheng, Zhengxiang Zhang
Jun 8, 2021·Journal of Parkinson's Disease·Ivette M SandovalFredric P Manfredsson
Jul 3, 2021·International Journal of Molecular Sciences·Antonella CardinaleBarbara Picconi
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Bipul RayMeena Kishore Sakharkar
Jul 22, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Faith L AndersonMatthew C Havrda
Aug 24, 2021·Frontiers in Aging Neuroscience·Maria Shadrina, Petr Slominsky
Aug 30, 2021·Acta Neuropathologica Communications·Ethan W HassBenoit I Giasson
Sep 26, 2021·Molecular Psychiatry·Yu-Jie GuoPeng Lei
Oct 24, 2021·Journal of Neurochemistry·Maksym GalkinVolodymyr V Shvadchak

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