PMID: 8944411Nov 1, 1996Paper

Initiation, maintenance and extinction of cocaine self-administration with and without conditioned reward

Psychopharmacology
R Ranaldi, D C Roberts

Abstract

Relapse prevention in abstinent cocaine addicts remains a major focus of drug addiction therapy. We used a rat model of cocaine addiction that focused on cocaine-seeking behavior elicited interoceptively and by conditioned stimuli. Each of 18 rats could self-administer a maximum of 20 intravenous cocaine injections (1.5 mg/kg) per session per day. To prevent initiation of responding by cocaine itself priming injections were never administered. Although cocaine was available beginning every session the rats displayed a self-imposed period of abstinence followed by a period of rapid consumption. The abstinence period was variable among rats but consistent for individual rats. In experiment 1 we studied the contribution of a CS+ (stimulus light and lever retraction) to the motivation to initiate and maintain a cocaine self-administration episode. We compared the number of responses the rats emitted to receive the first and subsequent injections of the day between a group responding on a fixed-ratio (FR) schedule (n = 6) and a group responding on a second-order (SO) schedule (n = 5) of reinforcement. For all rats the number of responses per injection was raised daily until a rat failed to consume more than four injections. The SO g...Continue Reading

Citations

Jan 18, 2007·Behavior Genetics·Morgane Thomsen, S Barak Caine
Oct 1, 1998·European Journal of Pharmacology·J PiaseckiP Bienkowski
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R D SpealmanT V Khroyan
Oct 23, 2003·Behavioral Neuroscience·Paul J KennyAthina Markou
May 14, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Justin T GassL Judson Chandler
Sep 25, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·David C S RobertsYu Liu
Sep 15, 2015·Pharmacology, Biochemistry, and Behavior·Joshua A PeckRobert Ranaldi
Sep 15, 2005·Neuron·Jonathan L C LeeBarry J Everitt
Sep 12, 2012·Behavioural Brain Research·Karen KestRobert Ranaldi
Jan 1, 2008·Drug Discovery Today. Disease Models·Jasmine J Yap, Klaus A Miczek
Feb 27, 2013·Neuroscience and Biobehavioral Reviews·Benjamin T Saunders, Terry E Robinson

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