Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinylcyclohexene diepoxide

Reproductive Toxicology
Patrick J DevineP B Hoyer

Abstract

Repeated daily dosing of rats with the ovotoxic, occupational chemical 4-vinylcyclohexene diepoxide (VCD, 80 mg/kg, i.p.) selectively depletes primordial and primary ovarian follicles. This study was designed to investigate whether follicle loss can be achieved following a single, acute exposure to VCD. Ovaries removed from postnatal-day-4 female Fischer 344 rats were cultured in the absence or presence of VCD for 15 days. Continuous in vitro exposure to VCD (15 days) caused concentration-dependent loss of primordial and small primary follicles. A single exposure to VCD in vitro (30 microM, 24 h) also caused significant losses of primordial and primary follicles 14 days later. Additionally, 28-day-old female rats were given a single injection of VCD (40-320 mg/kg, i.p.). A single dose at 320 mg/kg resulted in substantial loss of all follicle stages beginning 6 days later. Overall, these results demonstrate that an acute exposure to high concentrations/doses of VCD is sufficient to cause subsequent delayed loss of follicles.

References

Sep 15, 1990·Toxicology and Applied Pharmacology·B J SmithI G Sipes
Nov 1, 1994·Reproductive Toxicology·J A FlawsP B Hoyer
Jul 1, 1994·Reproductive Toxicology·S B HooserI G Sipes
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·P B Hoyer, I G Sipes
Aug 1, 1996·Toxicology and Applied Pharmacology·L N SpringerP B Hoyer
Jul 14, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·P J DevineP B Hoyer
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ellen A CannadyPatricia B Hoyer
Oct 29, 2002·Reproductive Toxicology·Loretta P MayerPatricia B Hoyer
Mar 5, 2004·Biology of Reproduction·Loretta P MayerPatricia B Hoyer

❮ Previous
Next ❯

Citations

Oct 29, 2011·Biology of Reproduction·Patrick J DevineUlrike Luderer
Feb 21, 2009·Human Reproduction·Anne Mulligan TuttleWarren G Foster
Oct 18, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anne Marie GannonWarren G Foster
Nov 15, 2011·Reproductive Toxicology·Noriyuki TakahashiBunpei Ishizuka
Feb 25, 2009·Brain Research·P Elyse SchauweckerAriana Lorenzana
Aug 26, 2014·Reproductive Toxicology·Agnes StefansdottirNorah Spears
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Sukhdeep K SahambiPatrick J Devine
Mar 8, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Patricia B Hoyer, I Glenn Sipes
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Lian Bao CaoWai Yee Chan
Dec 31, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Patrice Desmeules, Patrick J Devine
Jan 13, 2016·Alternatives to Laboratory Animals : ATLA·Wei LiuGuan-Wei Fan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.