Initiation of DNA interstrand cross-link repair in mammalian cells.

Environmental and Molecular Mutagenesis
Erica M HlavinPaul S Miller

Abstract

Interstrand cross-links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross-linking agents are well established in clinical use, and numerous repair proteins have been implicated in the initial events of mammalian ICL repair, the precise mechanistic details of these events remain to be elucidated. This review will summarize our current understanding of how ICL repair is initiated with an emphasis on the context (replicating, transcribed or quiescent DNA) in which the ICL is recognized, and how the chemical and physical properties of ICLs influence repair. Although most studies have focused on replication-dependent repair because of the relation to highly replicative tumor cells, replication-independent ICL repair is likely to be important in the circumvention of cross-link cytotoxicity in nondividing, terminally differentiated cells that may be challenged with exogenous or endogenous sources of ICLs. Consequently, the ICL repair pathway that should be considered "dominant" appears to depend on the cell type and the DNA context in which the ICL is encountered. The ability to define a...Continue Reading

References

Dec 1, 1979·Photochemistry and Photobiology·J H Robbins
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I MellonP C Hanawalt
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R S Cole
Nov 1, 1980·Photochemistry and Photobiology·P G Parsons, P Goss
Aug 11, 1994·Nucleic Acids Research·F Larminat, V A Bohr
Jun 11, 1996·International Journal of Cancer. Journal International Du Cancer·G DamiaM D'Incalci
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·B S AnderssonD Murray
Feb 7, 1997·The Journal of Biological Chemistry·T BesshoM P Thelen
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·A S BalajeeV A Bohr
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·C P Selby, A Sancar
Feb 24, 2000·Nucleic Acids Research·L LiR J Legerski
Mar 14, 2000·Molecular and Cellular Biology·D MuA Sancar
Jul 7, 2000·The Journal of Biological Chemistry·I KuraokaR D Wood
Aug 23, 2001·Mutation Research·M L Dronkert, R Kanaar
Feb 19, 2002·Chemical Reviews·Scott R. Rajski, Robert M. Williams
Mar 9, 2002·Molecular and Cellular Biology·Nianxiang ZhangRandy J Legerski
Mar 22, 2002·The Lancet Oncology·P J McHughJ A Hartley
Dec 11, 2002·The Journal of Biological Chemistry·Tadayoshi Bessho
Jan 8, 2003·Journal of the American Chemical Society·Ivan D KozekovThomas M Harris

❮ Previous
Next ❯

Citations

Aug 24, 2010·Cellular and Molecular Life Sciences : CMLS·Angelo Guainazzi, Orlando D Schärer
Dec 23, 2010·Biochemistry·Joshua I FriedmanJames T Stivers
Jun 15, 2012·The Journal of Biological Chemistry·Danielle L DaeeKyungjae Myung
Apr 17, 2012·Journal of the National Cancer Institute·Josephine KangDavid Kozono
Oct 16, 2012·Genome Integrity·Danielle L Daee, Kyungjae Myung
Jun 30, 2012·Cellular and Molecular Life Sciences : CMLS·Mathew J K Jones, Tony T Huang
Dec 12, 2012·Mutation Research·Anbarasi Kothandapani, Steve M Patrick
Nov 14, 2015·Archives of Toxicology·Shiyao ZhuZheng Dong
Oct 16, 2012·Environmental and Molecular Mutagenesis·Shilpy Sharma, Christine E Canman
Jul 19, 2013·European Journal of Haematology·Pallavi ShuklaBabu Rao Vundinti
Jun 5, 2012·Molecular Cell·Hannah L WilliamsJean Gautier
Nov 6, 2013·FEMS Microbiology Reviews·Carlo VitiLuciana Giovannetti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.