Initiation of DNA replication in eukaryotic cells

Annual Review of Cell and Developmental Biology
Anindya Dutta, Stephen P Bell

Abstract

The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.

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Datasets Mentioned

BETA
GM52339

Methods Mentioned

BETA
footprinting
cross-linking studies
two-hybrid
immunoprecipitation
immunoprecipitations
co-immunoprecipitation

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