Initiation of DNA replication in Xenopus egg extracts

Frontiers in Bioscience : a Journal and Virtual Library
Emily E Arias, Johannes C Walter

Abstract

In the last decade, extraordinary advances in our understanding of the initiation step of eukaryotic DNA replication have been achieved. Many factors required for replication initiation have been identified, and an elegant model to explain how DNA replication is restricted to a single round per cell cycle has emerged. Of the many experimental approaches used to study DNA replication, egg extracts from Xenopus laevis are among the most powerful, since they recapitulate a complete round of cell-cycle regulated chromosomal DNA replication in vitro. In this review, we discuss current models for how DNA replication is initiated and regulated in Xenopus eggs, and we highlight similarities and differences seen between this and the other most common experimental organisms, yeast and humans.

Citations

Aug 30, 2008·The Journal of Biological Chemistry·Christopher R HouchensThomas J Kelly
Feb 25, 2009·Nucleic Acids Research·Liliana Krasinska, Daniel Fisher
Sep 1, 2006·Molecular and Cellular Biology·Christo P ChristovTorsten Krude
Jul 28, 2011·Molecular and Cellular Biology·Clara CollartTorsten Krude
Nov 7, 2009·Disease Models & Mechanisms·Marie K Cross, Maureen A Powers
Apr 14, 2010·The Journal of Cell Biology·Christopher VanKarlene A Cimprich
Aug 30, 2005·Biochemical and Biophysical Research Communications·Xiaoyan LuRandy Legerski
Dec 27, 2006·Methods : a Companion to Methods in Enzymology·Patrick J LupardusKarlene A Cimprich
Dec 20, 2005·Nature Cell Biology·Emily E Arias, Johannes C Walter
Oct 7, 2017·The EMBO Journal·Nikolaos ParisisDaniel Fisher

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