Initiation of extended release naltrexone (XR-NTX) for opioid use disorder prior to release from prison

Journal of Substance Abuse Treatment
Peter D FriedmannJennifer Clarke

Abstract

Opioid use disorder is common in prison populations, and prison release is a high-risk time for relapse and overdose. Initiation of extended release injectable naltrexone (XR-NTX)) prior to prison release might decrease relapse among opioid-dependent persons. This pilot study examined the feasibility and acceptability of XR-NTX injection prior to prison release among adult inmates with opioid use disorder, followed by six months of community XR-NTX treatment. It sought to determine effects on treatment retention and abstinence compared to post-release XR-NTX initiation. Recruitment for the study took place at the RIDOC's Adult Correctional Institute (ACI). Volunteers with a history of opioid dependence and a release date scheduled within 1-2months were self-referred in response to recruitment fliers. Consented volunteers were randomized to XR-NTX treatment prior to release followed by 5 monthly treatments in the community (pre-release) or six XR-NTX treatments in the community (post-release). Of 26 volunteers consented, 15 were randomized (9 pre-release, 6 post-release). The pre-release group generally had better treatment retention: 100% received the first NTX injection (vs. 67% post-release), 78% received more than one inject...Continue Reading

Citations

Feb 6, 2018·Addiction·Brantley P JarvisKenneth Silverman
Jun 6, 2019·The New England Journal of Medicine·Kavita M BabuDavid N Juurlink
Oct 8, 2019·The Cochrane Database of Systematic Reviews·Amanda E PerryShilpi Swami
Dec 14, 2019·The Cochrane Database of Systematic Reviews·Amanda E PerryKath Wright
Jan 15, 2020·BMJ : British Medical Journal·F W ArnoldJ Payne-James
Sep 22, 2020·Journal of Addiction Medicine·Brian ChanJeanne-Marie Guise
Jun 24, 2020·Peptides·Richard J Bodnar
May 28, 2021·Patient Preference and Adherence·Virginia Perez-MaciaLorena Garcia-Fernandez

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