Initiation of insulin pump therapy in children at diagnosis of type 1 diabetes resulted in improved long-term glycemic control

Pediatric Diabetes
Eunice G LangDeborah C Foskett

Abstract

Insulin pump therapy (IPT) is increasingly used in children and young people with type 1 diabetes. There are limited studies evaluating the optimal time to start IPT. The aim of this study was to determine if early initiation of IPT in children with type 1 diabetes leads to improved glycaemic control and quality of life (QOL) compared with the later introduction of IPT. There were 38 subjects in the early pump group (EPG) (age 12.6 + 4.9 yr, 23 male) and 37 in the later pump group (LPG) (age 13.1 + 4.1 yr, 19 male). Hemoglobin A1c (HbA1c), rate of severe hypoglycemia, and diabetic ketoacidosis (DKA) were collected retrospectively over a 48-month period. Eligible subjects and/or their parents completed both a Paediatric and Paediatric Diabetes-specific Quality of Life Inventory. HbA1c measurements were lower in the EPG (6.8%; 51 mmol/mol) compared to the LPG (7.9%; 63 mmol/mol), across the 48 months of the study (p < 0.0001). There was no significant difference in the rate (per patient years) of severe hypoglycaemia (0.02; 0.07) p = 0.075 between the two groups. There were no episodes of DKA in either group. There was no significant difference in QOL between the groups with both having high satisfaction rates. Initiation of IPT ...Continue Reading

References

Nov 18, 2006·Diabetes Technology & Therapeutics·Neesha RamchandaniNoel K Maclaren
Sep 1, 2011·Diabetes Research and Clinical Practice·Olga KordonouriThomas Danne
Jan 31, 2012·Diabetes Technology & Therapeutics·Shlomit ShalitinMoshe Phillip
Oct 17, 2013·Diabetes Care·Bruce BuckinghamUNKNOWN Type 1 Diabetes TrialNet Study Group
Aug 28, 2014·Diabetes Technology & Therapeutics·Davide BrancatoVincenzo Provenzano

❮ Previous
Next ❯

Citations

Jul 8, 2017·Diabetes Technology & Therapeutics·Asma Deeb
Jul 4, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Anna KadłubiskaWłodzimierz Łuczyński
Dec 14, 2019·American Journal of Therapeutics·Revital NimriMoshe Phillip
Jun 4, 2019·Journal of Paediatrics and Child Health·Lindsey J Ross, Kristen A Neville
Jan 26, 2020·Endocrinology and Metabolism Clinics of North America·Hannah R DesrochersLori M Laffel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.