Initiation of sodium spikelets in basal dendrites of neocortical pyramidal neurons.

The Journal of Membrane Biology
Bogdan A MilojkovicSrdjan D Antic

Abstract

Cortical information processing relies critically on the processing of electrical signals in pyramidal neurons. Electrical transients mainly arise when excitatory synaptic inputs impinge upon distal dendritic regions. To study the dendritic aspect of synaptic integration one must record electrical signals in distal dendrites. Since thin dendritic branches, such as oblique and basal dendrites, do not support routine glass electrode measurements, we turned our effort towards voltage-sensitive dye recordings. Using the optical imaging approach we found and reported previously that basal dendrites of neocortical pyramidal neurons show an elaborate repertoire of electrical signals, including backpropagating action potentials and glutamate-evoked plateau potentials. Here we report a novel form of electrical signal, qualitatively and quantitatively different from backpropagating action potentials and dendritic plateau potentials. Strong glutamatergic stimulation of an individual basal dendrite is capable of triggering a fast spike, which precedes the dendritic plateau potential. The amplitude of the fast initial spikelet was actually smaller that the amplitude of the backpropagating action potential in the same dendritic segment. Ther...Continue Reading

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Citations

Sep 27, 2006·Pflügers Archiv : European journal of physiology·Greg J Stuart, Lucy M Palmer
Feb 17, 2009·Brain Cell Biology·Michelle Z L KeeYuko Sekino
Jul 12, 2013·Annual Review of Neuroscience·Guy MajorJackie Schiller
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Oct 9, 2014·Frontiers in Cellular Neuroscience·Cuiping TianYousheng Shu
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Jun 15, 2010·Journal of Neuroscience Research·Srdjan D AnticKaterina D Ikonomu
Oct 31, 2019·ELife·Aaron KerlinKarel Svoboda
Oct 16, 2019·Frontiers in Molecular Neuroscience·Elisabete Augusto, Frédéric Gambino
Apr 11, 2018·Journal of Neuroscience Research·Srdjan D AnticWilliam W Lytton
Jun 5, 2021·Current Opinion in Neurobiology·Spyridon Chavlis, Panayiota Poirazi

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