Initiation of TCR phosphorylation and signal transduction.

Frontiers in Immunology
Nicholas R J GascoigneVasily Rybakin

Abstract

Recent data with CD8+ T cells show that the initial phase of T cell receptor (TCR) binding to MHC-peptide (MHCp) is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the bound TCR before the co-receptor binds to MHCp?

Citations

Jun 22, 2014·Trends in Immunology·Guo FuNicholas R J Gascoigne
Oct 8, 2016·Annual Review of Cell and Developmental Biology·Nicholas R J GascoigneJoanna Brzostek
Nov 28, 2014·Nature Communications·Javier CasasNicholas R J Gascoigne
Jul 3, 2019·The Biochemical Journal·Vasily RybakinGhislain Opdenakker
Jan 24, 2017·Transplantation·Joanna Brzostek, Nicholas R J Gascoigne
Aug 16, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas P GoplenEmma Teixeiro
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alejandro Martín-ÁvilaClaudia González-Espinosa
May 27, 2020·Cellular & Molecular Immunology·Ling WuNicholas R J Gascoigne
Dec 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kiera L ClaytonMario A Ostrowski
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Qianru WeiNicholas R J Gascoigne
May 4, 2021·Frontiers in Immunology·Wan-Lin Lo, Arthur Weiss

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Methods Mentioned

BETA
transgenic
myristoylation
acylation
FRET
super-resolution microscopy

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