PMID: 8943765Oct 1, 1996Paper

Initiation of the oestradiol-induced inhibition of pulsatile LH secretion in ewes under long days: comparison of peripheral versus central treatment and neurochemical correlates

The Journal of Endocrinology
J Gallegos-SánchezJ C Thiéry

Abstract

In the ewe, the inhibition of pulsatile LH secretion by oestradiol during long days depends on dopaminergic activity and could involve amino acid transmitters. In the first experiment of the present study we observed the changes in LH secretion in ovariectomised ewes under long days immediately after subcutaneous implantation of oestradiol (peripheral treatment). In the second experiment, in order to identify the site of action of oestradiol, we observed the LH changes following intracerebral infusion of oestradiol through a microdialysis membrane (central treatment) within the preoptic area, the mediobasal hypothalamus (MBH) or the retrochiasmatic area (RCh) and measured amino acids and catecholaminergic transmitters and metabolites within the dialysates. With peripheral treatment, the amplitude, the nadir and the area under the LH pulse curve decreased within 4 to 8 h of the insertion of a subcutaneous oestradiol implant. After 18 h, the amplitude and the area under the pulses increased, as well as the intervals between pulses (from 49.9 + 1.4 min to 75.6 +/- 5.9 min). With central oestradiol treatment. LH changes were similar whatever the site of oestradiol infusion, suggesting either multiple sites of action or diffusion be...Continue Reading

Citations

Dec 8, 2000·Steroids·N Chabbert-BuffetaP Bouchard
Jul 27, 2002·Domestic Animal Endocrinology·J C ThiéryB Malpaux
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·D C SkinnerA Caraty
Mar 20, 2010·Molecular and Cellular Endocrinology·Jeremy T Smith, Iain J Clarke
Aug 14, 1999·Journal of Neuroendocrinology·D C SkinnerA Caraty

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