Injectable alginate hydrogels for cell delivery in tissue engineering

Acta Biomaterialia
Sílvia J BidarraPedro L Granja

Abstract

Alginate hydrogels are extremely versatile and adaptable biomaterials, with great potential for use in biomedical applications. Their extracellular matrix-like features have been key factors for their choice as vehicles for cell delivery strategies aimed at tissue regeneration. A variety of strategies to decorate them with biofunctional moieties and to modulate their biophysical properties have been developed recently, which further allow their tailoring to the desired application. Additionally, their potential use as injectable materials offers several advantages over preformed scaffold-based approaches, namely: easy incorporation of therapeutic agents, such as cells, under mild conditions; minimally invasive local delivery; and high contourability, which is essential for filling in irregular defects. Alginate hydrogels have already been explored as cell delivery systems to enhance regeneration in different tissues and organs. Here, the in vitro and in vivo potential of injectable alginate hydrogels to deliver cells in a targeted fashion is reviewed. In each example, the selected crosslinking approach, the cell type, the target tissue and the main findings of the study are highlighted.

References

Mar 1, 1990·Trends in Biotechnology·O Smidsrød, G Skjåk-Braek
Aug 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G MajmudarJ Bonadio
Jan 23, 1999·Biomaterials·J A RowleyD J Mooney
Jun 6, 2000·Advanced Drug Delivery Reviews·S Wee, W R Gombotz
Nov 15, 2000·Journal of Biomedical Materials Research·K A SmedsM W Grinstaff
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A E BaerL A Setton
Nov 17, 2001·Chemical Reviews·K Y Lee, D J Mooney
Jan 5, 2002·Journal of Dental Research·E AlsbergD J Mooney
Oct 25, 2002·Journal of Microencapsulation·T I Klokk, J E Melvik
Apr 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·M P LutolfJ A Hubbell
Jul 2, 2003·Biomaterials·Hyun Joon KongDavid J Mooney
Aug 19, 2003·Biomaterials·Jeanie L Drury, David J Mooney
Aug 19, 2003·Biomaterials·Ulrich HerselHorst Kessler
Jan 7, 2004·Journal of Agricultural and Food Chemistry·Dong Wook LeeChong M Lee
Jan 13, 2004·Biomacromolecules·Ivan DonatiSergio Paoletti
Jan 31, 2004·Biomaterials·Kuen Yong LeeDavid J Mooney
Feb 26, 2004·Biomaterials·Jeanie L DruryDavid J Mooney
Mar 30, 2004·Biomaterials·C C RibeiroM A Barbosa
Jul 13, 2004·The Journal of Urology·Amanda J ThorntonDavid J Mooney
Sep 18, 2004·Journal of Biomedical Materials Research. Part a·Nikhil O DhootMargaret A Wheatley
Apr 1, 2005·Journal of Microencapsulation·W F KendallE C Opara
Jul 9, 2005·Circulation Research·Michael E DavisRichard T Lee
Jul 9, 2005·Nature Biotechnology·Rakesh K JainDai Fukumura
Jul 20, 2005·Journal of Biomedical Materials Research. Part a·C C BarriasM A Barbosa
May 6, 2006·Tissue Engineering·Julia F MarkusenPeter Dunnill
May 9, 2006·Biomacromolecules·Yrr A MørchGudmund Skjåk-Braek
Jun 15, 2006·Tissue Engineering·Elliott HillDavid J Mooney
Jul 4, 2006·Biochemical and Biophysical Research Communications·S A AbbahK D K Luk
Aug 2, 2006·Macromolecular Bioscience·Alexander D AugstDavid J Mooney
Sep 5, 2006·Journal of the American College of Cardiology·Karen L Christman, Randall J Lee
Oct 5, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Steve W N UengShih-Jung Liu
Nov 25, 2006·Biomaterials·John T ConnellyMarc E Levenston
Dec 1, 2006·Journal of Materials Science. Materials in Medicine·S A AbbahK D K Luk

❮ Previous
Next ❯

Citations

Jan 31, 2016·Journal of Biomedical Materials Research. Part a·Adam Saltz, Umadevi Kandalam
Oct 31, 2015·Journal of Biomedical Materials Research. Part a·Yo-Shen ChenFeng-Huei Lin
Jan 9, 2016·Dental Materials : Official Publication of the Academy of Dental Materials·Ping WangHockin H K Xu
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Emily A Growney KalafScott A Sell
Dec 17, 2015·Stem Cell Research & Therapy·Isaac Perea-GilAntoni Bayes-Genis
Jul 30, 2015·Acta Biomaterialia·Jonathan M GrasmanGeorge D Pins
Aug 19, 2015·Biomacromolecules·Sajeesh Kumar Madhurakkat PerikamanaHeungsoo Shin
Aug 5, 2015·Journal of Biomedical Science·Hsien-Tseng LuChien-Ho Chen
May 7, 2016·Journal of Tissue Engineering and Regenerative Medicine·Nelson Monteiro, Pamela C Yelick
Jul 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Roberta S StilhanoEduardo A Silva
Jul 28, 2016·Journal of Orthopaedic Surgery and Research·Claudia FuocoCesare Gargioli
Dec 10, 2016·Journal of Biomedical Materials Research. Part a·Pujiang ShiWai Yee Yeong
Jan 29, 2016·Biomaterials Science·Santiago GrijalvoDavid Díaz Díaz
Aug 18, 2017·Chemical Society Reviews·Qiutong HuangJianzhong Du
Jul 5, 2018·International Journal of Molecular Sciences·Fabien NativelGael Grimandi
Aug 4, 2018·Advanced Materials·Chunfeng WangSheng Xu
Sep 4, 2018·Advanced Healthcare Materials·Nicola C HuntMajlinda Lako
Sep 22, 2018·Biomaterials Science·Laura J MacdougallAndrew P Dove
May 11, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ran AnAnnika Weigand
Oct 29, 2018·Macromolecular Bioscience·Hector Lopez HernandezEric A Appel
Nov 15, 2018·Journal of Biomaterials Applications·Jingwen WuLvhua Guo
Oct 26, 2018·Journal of Tissue Engineering and Regenerative Medicine·Sorour NematiReza Rahbarghazi
Jan 10, 2019·Advanced Healthcare Materials·Swetha RathanDaniel J Kelly
Jun 7, 2017·Bone Research·Mei LiuNongyue He
Jun 21, 2019·Scientific Reports·Yolanda Martín-MartínDaniel González-Nieto
Nov 16, 2019·Nanoscale·Ruirui XingXuehai Yan
Sep 10, 2019·Advanced Materials·Amanda L FacklamDaniel G Anderson
Dec 28, 2019·Pharmaceutics·Natallia DubashynskayaYury A Skorik
Jan 25, 2020·Advanced Healthcare Materials·Thomas E RobinsonSophie C Cox

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Fanglian YaoKangde Yao
Nature Nanotechnology
Sungjin Park, Rodney S Ruoff
Biotechnology Journal
Birsen DemirbagVasif Hasirci
© 2021 Meta ULC. All rights reserved