Injectable and tunable hyaluronic acid hydrogels releasing chemotactic and angiogenic growth factors for endodontic regeneration

Acta Biomaterialia
Cristiana R SilvaManuela E Gomes

Abstract

Bioengineered soft tissues on any meaningful scale or complexity must incorporate aspects of the functional tissue, namely a vasculature, providing cells oxygen and nutrients critical for their survival. However, the ability of tissue engineering strategies to promote a fast revascularization is critically limited. Particularly in endodontic regenerative therapies, the complicated anatomy of the root canal system, and the narrow apical access limit the supply of new blood vessels and pulp tissue ingrowth. Here we characterize the viscoelastic and microstructural properties of a class of injectable hyaluronic acid (HA) hydrogels formed in situ, reinforced with cellulose nanocrystals (CNCs) and enriched with platelet lysate (PL), and test its ability to promote cells recruitment and proangiogenic activity in vitro. The incorporation of CNCs enhanced the stability of the materials against hydrolytic and enzymatic degradation. Moreover, the release of the chemotactic and pro-angiogenic growth factors (GFs) (PDGF and VEGF) from the PL-laden hydrogels showed an improved sustained profile proportional to the amount of incorporated CNCs. The PL-laden hydrogels exhibited preferential supportive properties of encapsulated human dental pu...Continue Reading

Citations

Dec 21, 2018·Biomaterials Science·Ignacio Medina-Fernandez, Adam D Celiz
Oct 10, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Raquel Costa-AlmeidaManuela E Gomes
Jun 6, 2020·Expert Opinion on Drug Delivery·Anil Kishen, Hebatullah Hussein
Jul 10, 2019·Journal of Biomaterials Applications·Cristiana R SilvaAnthony Weiss
May 18, 2020·International Journal of Molecular Sciences·Håvard Jostein HaugenJanne Elin Reseland
Feb 2, 2019·Current Oral Health Reports·Henry F DuncanEmi Shimizu
Jul 6, 2020·Tissue Engineering and Regenerative Medicine·Mohammed E GrawishSalwa A El-Negoly
Dec 5, 2020·Advanced Healthcare Materials·Fatemeh PoustchiMohammad-Ali Shahbazi
Dec 16, 2020·Polymers·Marwa M S AbbassKarim M Fawzy El-Sayed
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ting YangWeidong Tian
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Junqing LiuChengfei Zhang
Mar 18, 2021·International Journal of Nanomedicine·Jasmine WongChengfei Zhang
Mar 18, 2021·APL Bioengineering·Arshia EhsanipourStephanie K Seidlits
Apr 21, 2021·Macromolecular Rapid Communications·Chunxiang MoYuping Chen
Apr 23, 2021·Journal of Endodontics·Maria Luísa LeiteCarlos Alberto de Souza Costa
May 15, 2021·International Journal of Biological Macromolecules·Layde T CarvalhoTalita M Lacerda
Jun 18, 2021·ACS Biomaterials Science & Engineering·M Isabel Rial-HermidaJoão F Mano
Jul 31, 2021·Journal of Dental Research·T ZouC Zhang
Aug 27, 2021·Macromolecular Rapid Communications·Xingchen LiQuan Lin
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David T WuSimon D Tran

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