Injectable biodegradable thermosensitive hydrogel composite for orthopedic tissue engineering. 1. Preparation and characterization of nanohydroxyapatite/poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel nanocomposites

The Journal of Physical Chemistry. B
Shao Zhi FuZhi Yong Qian

Abstract

In this study, we synthesized a biodegradable triblock copolymer poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) by ring-opening copolymerization, and nanohydroxyapatite (n-HA) powder was prepared by a hydrothermal precipitation method. The obtained n-HA was incorporated into the PECE matrix to prepare injectable thermosensitive hydrogel nanocomposites. (1)H NMR, FT-IR, XRD, DSC, and TEM were used to investigate the properties of PECE copolymer and n-HA/PECE nanocomposites. The rheological measurements for n-HA/PECE nanocomposites revealed that the gelation temperature was approximately 36 degrees C. The sol-gel-sol transition behavior and phase transition diagrams were recorded through a test tube inverting method. The results showed that n-HA/PECE nanocomposites still had thermoresponsivity like that of PECE thermosensitive hydrogel. The morphology of the nanocomposites was observed by SEM; the results showed that the nanocomposites had a 3D network structure. In addition, the effects of n-HA contents on the properties of n-HA/PECE nanocomposites are also discussed in the paper. From the results, n-HA/PECE hydrogel is believed to be promising for injectable orthopedic tissue engineer...Continue Reading

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Citations

Oct 22, 2010·Journal of Biomaterials Science. Polymer Edition·Xiu Hong WangZhi Yong Qian
Feb 18, 2014·Colloids and Surfaces. B, Biointerfaces·Özge ErdemliAyşen Tezcaner
Feb 12, 2013·Nanomedicine·Zhi-Yong QianSi-Shen Feng
May 14, 2016·ACS Biomaterials Science & Engineering·Artem B Kutikov, Jie Song
Apr 28, 2016·Expert Opinion on Drug Delivery·Anisha A D'souza, Ranjita Shegokar
Feb 12, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Heng ZhangShaoZhi Fu
Feb 13, 2013·Journal of Biomedical Materials Research. Part a·Michael B DreifkeAmbalangodage C Jayasuriya
Jun 7, 2017·Bone Research·Mei LiuNongyue He
Jun 13, 2012·Chemical Society Reviews·Hyo Jung MoonByeongmoon Jeong
Aug 27, 2013·Biomaterials Science·Dipendra GyawaliJian Yang
Jul 21, 2011·Journal of Biomaterials Science. Polymer Edition·Vivek Kumar GarripelliSeongbong Jo
Nov 28, 2012·Journal of Biomedical Materials Research. Part a·Shadab Bagheri-KhoulenjaniMohammad Ali Shokrgozar
Dec 3, 2010·Journal of Biomaterials Applications·Aya NagayasuKazushige Takehana
Nov 23, 2011·Journal of Biomedical Materials Research. Part a·Bei-Yu WangZhi-Yong Qian
Feb 4, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shao Zhi FuZhi Yong Qian
Mar 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Genyao LinBarbara J Tarasevich
Oct 9, 2018·Frontiers in Bioengineering and Biotechnology·Ignasi CasanellasJosep Samitier

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