Injectable cross-linked collagen with improved flow properties

Journal of Biomedical Materials Research
D G WallaceB B Pharriss

Abstract

Aqueous suspensions of glutaraldehyde cross-linked fibrillar collagen and non-cross-linked fibrillar collagen were examined by rheometry, particle size analysis, and microscopic techniques. Although cross-linked collagen suspensions were similar to non-cross-linked suspensions by microscopic and size analyses, they differed in rheometric properties. Concentric cylinder Couette flow, shear creep, uniaxial creep, and porous bed flow all revealed that cross-linked collagen was more resistant to deformation and flow than non-cross-linked collagen. These results were in agreement with in vivo dermal implantation studies, both in pig and human; i.e., compared to non-cross-linked collagen, the cross-linked formulation was more difficult to inject into tissue and did not spread uniformly, sometimes giving rise to palpable lumps or large masses evident in histological sections. When hyaluronic acid was blended with cross-linked collagen to achieve a final hyaluronate concentration of 5 mg/mL, there was a significant improvement in ease of injection into tissue. Rheometry on blends of hyaluronate and cross-linked collagen demonstrated that the blend required lower forces to achieve deformation and flow, compared to cross-linked collagen ...Continue Reading

References

Jan 1, 1985·Aesthetic Plastic Surgery·L S CoopermanB B Pharriss
Jul 1, 1987·Journal of Biomedical Materials Research·D G WallaceB Weiss
Oct 1, 1986·Biopolymers·D G WallaceS B Wade
Jan 1, 1986·Journal of Biomedical Materials Research·F DeLustroJ M McPherson
Jan 1, 1986·Journal of Biomedical Materials Research·J M McPhersonR Armstrong
Apr 1, 1984·The Laryngoscope·C N FordT F Warner

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Citations

Jul 19, 2002·Journal of Biomedical Materials Research·Hsiu-O HoMing-Thau Sheu
Nov 19, 2003·Advanced Drug Delivery Reviews·Donald G Wallace, Joel Rosenblatt
May 10, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess, M Schlapp
Aug 3, 2000·Journal of Biomechanical Engineering·D LaudeN Bachrach
Mar 19, 2014·Biopolymers·Sayani Chattopadhyay, Ronald T Raines
May 8, 2007·Journal of Materials Science. Materials in Medicine·Márcio de PaulaVirginia Conceição Amaro Martins
Jul 23, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Márcio de PaulaJosé Carlos da Silva Trindade
Feb 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·N DuraipandyManikantan Syamala Kiran
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess
Jul 1, 2021·Acta Biomaterialia·Malachy MaherGordon G Wallace

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