Injectable, degradable, electroactive nanocomposite hydrogels containing conductive polymer nanoparticles for biomedical applications

International Journal of Nanomedicine
Qinmei WangWei Teng

Abstract

Injectable electroactive hydrogels (eGels) are promising in regenerative medicine and drug delivery, however, it is still a challenge to obtain such hydrogels simultaneously possessing other properties including uniform structure, degradability, robustness, and biocompatibility. An emerging strategy to endow hydrogels with desirable properties is to incorporate functional nanoparticles in their network. Herein, we report the synthesis and characterization of an injectable hydrogel based on oxidized alginate (OA) crosslinking gelatin reinforced by electroactive tetraaniline-graft-OA nanoparticles (nEOAs), where nEOAs are expected to impart electroactivity besides reinforcement without significantly degrading the other properties of hydrogels. Assays of transmission electron microscopy, (1)H nuclear magnetic resonance, and dynamic light scattering reveal that EOA can spontaneously and quickly self-assemble into robust nanoparticles in water, and this nanoparticle structure can be kept at pH 3~9. Measurement of the gel time by rheometer and the stir bar method confirms the formation of the eGels, and their gel time is dependent on the weight content of nEOAs. As expected, adding nEOAs to hydrogels does not cause the phase separati...Continue Reading

Citations

Aug 6, 2016·Expert Opinion on Drug Delivery·Marlene LopesAntonio J Ribeiro
Dec 1, 2017·Frontiers in Physiology·Anne-Margaux CollignonGael Y Rochefort
Dec 15, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Toribio F Otero
Oct 1, 2020·Biomaterials Science·Iga CarayonBarthélémy Philippe
Apr 25, 2020·Gels·Cassandra J WrightTimothy W Hanks
Oct 20, 2020·Advanced Healthcare Materials·Fabio Rizzo, Nermin Seda Kehr
Nov 28, 2017·Biomacromolecules·Supachai Reakasame, Aldo R Boccaccini
Jul 16, 2019·ACS Applied Materials & Interfaces·Hao ChenGuanghui Gao

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Methods Mentioned

BETA
nuclear
dynamic
transmission electron microscopy
rheology
enzyme-linked immunosorbent assay
Scanning electron microscopy

Software Mentioned

eGel

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