PMID: 8948305Nov 1, 1996Paper

Injectable gold compounds: an overview

British Journal of Rheumatology
G Jones, P M Brooks

Abstract

Injectable gold compounds have enjoyed widespread, but occasionally controversial, use in rheumatoid arthritis since the 1920s. This overview examines the data from controlled trials and longer-term observational studies. We conclude that gold is equivalent to other widely used second-line agents in terms of efficacy. Toxicity profiles are similar, apart from methotrexate. It is most efficacious and toxic in the first 2 yr of treatment. There appears to be a dose-response relationship for both efficacy and toxicity. Gold is one of the few agents that decreases the rate of progression of erosions (RR 0.38, 95% CI 0.23-064). Gold compounds, therefore, have a definite place in the rheumatologist's armamentarium, but further research is required to determine optimal monitoring regimes as well as the role of maintenance therapy and combination therapy.

Associated Clinical Trials

Jan 4, 2018·Sten Rasmussen, MD, PhD

Citations

Oct 18, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K Zierold
Sep 30, 1999·Environmental Health Perspectives·P E Bigazzi
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Anna A ShvedovaBengt Fadeel
Jul 30, 2002·Alimentary Pharmacology & Therapeutics·A G FraserD P Jewell
Aug 25, 2012·Advanced Drug Delivery Reviews·Xue-Qing ZhangOmid C Farokhzad
Jan 11, 2013·Journal of Drug Delivery·Daniela De StefanoMaria Chiara Maiuri
Apr 6, 2005·Clinical and Experimental Immunology·F Goldblatt, D A Isenberg
Nov 26, 1999·Rheumatic Diseases Clinics of North America·E D Rosenstein, J R Caldwell
Oct 17, 2017·International Journal of Radiation Biology·So-Ra Kim, Eun-Hee Kim
Oct 26, 2005·Drugs & Aging·Ignazio OlivieriAngela Padula
Aug 1, 2018·Critical Reviews in Toxicology·Alan B G Lansdown
Sep 17, 2014·Advances in Skin & Wound Care·David B Violette

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