Injectable hyaluronic acid hydrogels with the capacity for magnetic resonance imaging

Carbohydrate Polymers
Daniel Bermejo-VelascoJöns Hilborn

Abstract

Monitoring hydrogel degradation in real time using noninvasive imaging techniques is of great interest for designing a scaffold in tissue engineering. We report the preparation of gadolinium (Gd)-labeled and injectable hyaluronic acid (HA) hydrogels that can be visualized using T1- and T2-weighted magnetic resonance imaging (MRI). An HA derivative functionalized with thiol and hydrazide was labeled using a diethylenetriaminepentaacetate complex modified with "clickable" dithiopyridyl functionalities (degree of modification was 3.77% with respect to HA repeat units). The HA derivative modified with cross-linkable groups and Gd complex exhibited relaxivities r1 = 3.78 mM-1s-1 and r2 = 56.3 mM-1s-1. A hydrazone hydrogel network was obtained by mixing Gd-labeled HA-hydrazide and HA-aldehyde derivatives. Enzymatic hydrogel degradation could be followed using MRI because the MR images showed great correlation with the hydrogel mass loss. Ex vivo MRI of injected Gd-labeled hydrogels demonstrated that they show a significant contrast difference (SNRcoronal = 456; SNRaxial = 459) from the surrounding tissues. These results indicate that our Gd-labeled HA hydrogel has great potential as an injectable biocompatible hydrogel that can be us...Continue Reading

Citations

Feb 27, 2021·Biomaterials Science·Feifei WangHongbo Zeng
Feb 23, 2021·Frontiers in Chemistry·Yanyu Zhang, Yishun Huang
May 13, 2021·ACS Biomaterials Science & Engineering·Yuxi C DongDavid P Cormode
Sep 26, 2019·ACS Applied Materials & Interfaces·Daniel Bermejo-VelascoOommen P Varghese

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