Injectable micellar supramolecular hydrogel for delivery of hydrophobic anticancer drugs

Journal of Materials Science. Materials in Medicine
CuiXiang FuGuangYong Lin

Abstract

In this paper, an injectable micellar supramolecular hydrogel composed of α-cyclodextrin (α-CD) and monomethoxy poly(ethylene glycol)-b-poly(ε-caplactone) (MPEG5000-PCL5000) micelles was developed by a simple method for hydrophobic anticancer drug delivery. By mixing α-CD aqueous solution and MPEG5000-PCL5000 micelles, an injectable micellar supramolecular hydrogel could be formed under mild condition due to the inclusion complexation between α-CD and MPEG segment of MPEG5000-PCL5000 micelles. The resultant supramolecular hydrogel was thereafter characterized by X-ray diffraction (XRD) and Scanning electron microscopy (SEM). The effect of α-CD amount on the gelation time, mechanical strength and thixotropic property was studied by a rheometer. Payload of hydrophobic paclitaxel (PTX) to supramolecular hydrogel was achieved by encapsulation of PTX into MPEG5000-PCL5000 micelles prior mixing with α-CD aqueous solution. In vitro release study showed that the release behavior of PTX from hydrogel could be modulated by change the α-CD amount in hydrogel. Furthermore, such supramolecular hydrogel could enhance the biological activity of encapsulated PTX compared to free PTX, as indicated by in vitro cytotoxicity assay. All these resul...Continue Reading

References

Jul 24, 2008·Chemical Society Reviews·Lin Yu, Jiandong Ding
May 24, 2012·Chemical Society Reviews·Xuzhou YanFeihe Huang
Aug 15, 2012·Chemical Society Reviews·Eric A AppelOren A Scherman
May 16, 2013·Advanced Drug Delivery Reviews·Jianxiang Zhang, Peter X Ma
May 13, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Narendra K Singh, Doo Sung Lee
Nov 6, 2014·ACS Applied Materials & Interfaces·Jing YuYan-ping Shi

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Citations

Sep 25, 2019·Pharmaceutics·Giuseppe CirilloFrancesca Iemma
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bartłomiej KostTadeusz Biela
Jan 8, 2020·Materials·Adrian DomińskiPiotr Kurcok

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