Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion

International Journal of Biological Macromolecules
Sumi BangOh Hyeong Kwon

Abstract

Methods for reducing and preventing postoperative abdominal adhesions have been researched for decades; however, despite these efforts, the formation of postoperative peritoneal adhesions is continuously reported. Adhesions cause serious complications such as postoperative pain, intestinal obstruction, and infertility. Tissue adhesion barriers have been developed as films, membranes, knits, sprays, and hydrogels. Hydrogels have several advantages when used as adhesion barriers, including flexibility, low tissue adhesiveness, biodegradability, and non-toxic degraded products. Furthermore, compared with preformed hydrogels, injectable hydrogels can fill and cover spaces of any shape and do not require a surgical procedure for implantation. In this study, pullulan was modified through reaction with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) to introduce carboxyl and phenyl groups as crosslinking sites. The grafting of tyramine on pullulan allows crosslinking branches on pullulan backbone. We successfully fabricated pullulan hydrogel with an enzymatic reaction using horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The chemical structure of modified pullulan was ana...Continue Reading

References

Dec 31, 2002·Biomaterials·Yong Doo ParkJeffrey A Hubbell
Feb 14, 2007·Journal of Biomedical Materials Research. Part a·Aude AutissierCatherine Le Visage
Oct 6, 2010·Tissue Engineering. Part a·Victor W WongGeoffrey C Gurtner

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Citations

Jun 11, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jae Eok KoOh Hyeong Kwon
Aug 27, 2016·Carbohydrate Polymers·Ram Sarup SinghJohn F Kennedy
Jun 6, 2017·Current Opinion in Obstetrics & Gynecology·Esther S HanKaren C Wang
Jun 28, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei WuBruno Sarmento
May 2, 2018·Biomaterials Science·Mehdi KhanmohammadiJafar Ai
Nov 3, 2020·International Journal of Biological Macromolecules·Ram Sarup SinghJohn F Kennedy
Mar 13, 2021·Biomaterials Science·Bahareh Kheilnezhad, Afra Hadjizadeh
May 4, 2021·Chemical Reviews·Santiago CorreaEric A Appel
Dec 30, 2018·International Journal of Biological Macromolecules·Zhigang SongFei Liu
Aug 4, 2018·International Journal of Biological Macromolecules·Shazia TabasumKhalid Mahmood Zia

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